Regarding the Casimir effect - one might try to argue that the negative pressure between two conductive plates in the classic Casimir experiment arises because the vacuum outside the plates has a higher pressure than the vacuum between them.
There's a very simple way to see that this cannot be the explanation. Consider a variation on the experiment, where the plates are replaced by a periodic boundary condition. In other words, imagine that the universe in at least one direction is wrapped around in a circle (never mind whether it's possible to do this experimentally - although it actually may be - just think of it as a math exercise). There's no distance between the plates (because there are no plates), but there's a distance around the circle that plays the same role. Most importantly, there's no space "outside" the plates.
It turns out when you do that, you get a Casimir force that either tries to make the circle bigger or smaller, depending on the types of particles you have in your theory. So you can have pressure of either sign, and it manifestly has nothing to do with the pressure "outside" - because there is no outside.
Everything I have read--and I do not pretend to understand it all--indicates that, despite the denial from another poster, this is indeed a quantum effect. Some posters are apparently trying to use it as proof that "Einstein was Wrong
TM"
The curvature of space indicated above is not an observed (or observable) thing, AFAICS, and there may be other reasons for the force between the plates. The phenomenon is still being investigated.
I will stipulate that the Casimir Effect is real, but that's as far as I am willing to go.
In the practical world, Force is a function of mass, acceleration, pressure, area, magnetic force, spring constant, distance, and a large number of other things. While Casimir Effects may (and apparently are) significant in some Nano-technology applications, from my standpoint, it's just something else to be accounted for, and it's actual cause is for the real eggheads to bother over.
Like gravity, inertial, stiffness, magnetic, and other forces, whether it is caused by gravitons, electrons , or gypsy pygmy fairies is of interest to me, but the cause doesn't keep me from considering the effects.