Calorie restriction can help you live longer

First, as someone who has done this for a few years now, "calorie restriction" is not recommended. The "eat less move more" approach to losing weight is a long term failure, because it assumes a one-compartment model for calories that doesn't exist in reality. Do not, I repeat, do not, count calories, or abstain from eating to satiety when you're hungry. It only serves to slow your metabolism, and make you cold and miserable.

Do eat a ketogenic, or at least a low-carbohydrate diet, and eat infrequently (fast, but eat to satiety, once or twice a day). The reason for this is that of the three macronutrients, carbs, proteins, and fats, carbohydrates trigger the production of the most insulin by far, with (healthy, monounsaturated or polyunsaturated) fats resulting in the least insulin production. Insulin is the fat regulating hormone, and the high-carb western diet and frequency of eating, and snacking results in an abundance of insulin in the body, which results in insulin resistance, and thus more fat storage.

The starving kids in India are malnourished, not fasting, a profound difference.

But somewhere between overfed Americans and "the starving children of India" would be a calorie restricted but healthy population. 150 countries, there would be a curve. What is the peak?
 
But somewhere between overfed Americans and "the starving children of India" would be a calorie restricted but healthy population. 150 countries, there would be a curve. What is the peak?

Japan?

But I'm not really sure your logic actually follows. it's not clear that there is any population that's engaging in calorie restriction with a fully nutritious diet.
 
Can't compare the starving children in India with the Obese full plates people in America. Dumb thinking.

With age, I need and want less and certainly no more full plates as I did in my growing years. Grazing and good sense.
 
Louden (addressing you specifically because you seem to pretty informed on the topic), my understanding is that the life extension effects of calorie restriction seem to diminish with the size of the animals studied: so very effective in mice and a wide range of other animals of that size and smaller, where life (and health)spans increase as much as 50%, much less effective in dogs, not much clear effect in monkeys, and very ambiguous results in people. Still some evidence of an effect in people, so may be worth doing and certainly worth continued study.

Approximately correct?

It's not controversial among the folks doing the research (that calorie restriction works across animals, including us). I've been to a couple big aging meetings (while at a biotech doing aging research) and have a former grad student who spent a decade at the Buck Institute - now a faculty member at the new Tufts aging institute. Bigger/longer lived mammals are hard to do experiments with - the monkey study was complicated by the fact one of the two cohorts (U Wisconsin & NIH- I believe the latter - heard one of the authors speak) - had less impressive results relative to their internal controls, which had a junk food diet. The kicker was that they were feeding the animals only 1 meal a day - which is of course one of the popular approaches (some times called IF, but more properly time-restricted eating). Turns out the health indicators in the junk food one meal/day cohort were better than other all you can eat groups.

CR has also worked in a host of other animals, so no reason to think it's a lab mouse (which do have an unnatural genetic make-up) fluke. Importantly, We also know several independent mechanisms that contribute to the effects - e.g. the beneficial autophagy that fasting induces and the fact that nutrients (some of the amino acids in particular) stimulate mTOR - we know that mTOR inhibition lengthens lifespan - the mechanism behind rapamycin.

Other comments:
Yes, catsmate I'm aware it's not a top tier journal, but this is a *free* review, which has >100 refs.

As Caroline13 and several of you noted, yes it's calorie restriction without malnutrition - sometimes called CRON (Calorie Restriction with Optimal Nutrition)

Good question on natural experiments - worth looking up Okinawa prior to the more recent changes in diets- As I recall there was some good data there - briefly reviewed here. Also worth remembering that it's health span as well as life span that we're trying to maximize. The primary reason (at least among the people in that field that I've heard speak &/or talked to) that calorie restriction isn't pushed more is that they don't think that people (generally) can comply with it. And of course there will be $$ to be made by developing compounds that can mimic the effects (along with other anti-aging approaches)

So - many of us think it's worth incorporating some aspect of CR/IF/TRF into your life - plenty to gain and little to lose (except weight)
 
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