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Autism linked to NOT having MMR vaccine

Deetee

Illuminator
Deetee
Joined
Jul 8, 2003
Messages
3,789
Well, not really.
;)
But one could interpret the results of the latest study that failed to find a link between MMR vaccination and autism as demonstrating vaccination is protective:
Only 29% (20/70) of children who had a local diagnosis of ASD received MMR2 compared with 50% (14/28) who had no local ASD diagnosis.​
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For those who can't access it, here is the abstract.

A prediction: The study is bound to be dismissed by the antivaxers - not because of the science, but because some of the authors (experts in autism or vaccination) were involved in acting as experts in cases of litigation.

Times UK article here.
 
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Comments are filling up on the Times response section - almost all from antivaxers shooting from the hip and without a valid opinion on the actual paper's data or conclusions.

Also JABS have picked it up, predictably.

ETA Here is a link to the study in full.
 
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Deetee said:
For those who can't access it, here is the abstract.

A prediction: The study is bound to be dismissed by the antivaxers - not because of the science, but because some of the authors (experts in autism or vaccination) were involved in acting as experts in cases of litigation.
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Guess who's shown up in the eLetters. You got the wrong conspiracy theory though:
The NAS warning relates to the GMC hearing involving doctors Wakefield, Walker-Smith and Murch which is set to resume on 25 March approaching. I do not think it is being unduly cynical to query the publication of this study at the present time as a media event, bearing in mind that it seems to have been carried out five or six years ago.
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I also see I've not been keeping up with the interweb thingie - both the Grauniad comments and Badscience are full of several pages of posts. I have some reading to do.......
 
JABS now have a response by Wakefield to the Baird paper on their forum.

He seems to say that the Baird study did not look hard enough for kids with possible bowel symptoms. Any excuse to negate the study's findings, I suppose. In Wakefield's mind, MMR not only causes autism, but is meant to do so by provoking inflammation of the bowel. When researchers look for evidence of bowel problems in autistics, and find very little, Wakefield says the diagnostic bar is too high, and we must accept almost any bowel upset as a sign of disease. He even says that abdominal pain might not be evident in an autistic child, and so we should take other observations such as aggressive outbursts, sleep disturbance etc as indicators. In his world, where everything can be reinterpreted to reveal what he wants, this attitude is unsurprising.
 
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Mojo said:
You got the wrong conspiracy theory though:
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No I didn't - you just didn't give them time enough to come up with it.

The latest letter is from "Dr Carley". Her web site is a real doozy.
Dr. Carley has not only explained the mechanism by which inoculations corrupt the immune system and cause all auto-immune diseases and cancer in her white paper entitled “Inoculations: the True Weapons of Mass Destruction”; but also has developed the “Hippocrates Protocol”, which reverses all autoimmune diseases and cancer using natural therapies.

Dr. Carley is NOT licensed to practice medicine, and can never be licensed, as to do so would be a conflict of interest since licensure would force Dr. Carley to promote inoculations.

Dr. Carley is not board certified as she is developing the specialty of VIDS; but will soon be offering a course to train and certify healers how to create Hippocrates protocols for their clients (people or pets), based on their individual history. Contact Dr. Carley if you are interested in taking this course.
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:eek:
 
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Deetee said:
JABS now have a response by Wakefield to the Baird paper on their forum.

He seems to say that the Baird study did not look hard enough for kids with possible bowel symptoms. Any excuse to negate the study's findings, I suppose. In Wakefield's mind, MMR not only causes autism, but is meant to do so by provoking inflammation of the bowel. When researchers look for evidence of bowel problems in autistics, and find very little, Wakefield says the diagnostic bar is too high, and we must accept almost any bowel upset as a sign of disease. He even says that abdominal pain might not be evident in an autistic child, and so we should take other observations such as aggressive outbursts, sleep disturbance etc as indicators. In his world, where everything can be reinterpreted to reveal what he wants, this attitude is unsurprising.
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I am not on the MMR is bad side of the fence but I have to say I thought bowel problems and autism often went hand in hand. My daughter cetainly has severe ulcerative colitis and was very ill for the best part of a year - her blood count went down to single figures and her weight down to 6 stone. She is on permanent medication but it is now under control. I recall a documentary where a doctor looking at this problem said that there was a link between autism and gut problems but that in his view the autism caused the gut problem not vice versa. The argument he was countering being that MMR affected the auto-immune system which in turn affected the gut which in turn caused autism.
 
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I know there is a higher than expected association between autism and gut problems, including colitis. However there seems to be a consensus among experts in the field of paediatric gastroenterology that "autistic enterocolitis" is not a new/specific entity, and the fact that Wakefield diagnoses this frequently in autistic children probably is a reflection of his obsession with the illness.
 
CONCLUSION: Ileo-colonic LNH is a characteristic pathological finding in children with ASD and gastrointestinal symptoms, and is associated with mucosal inflammation. Differences in age at colonoscopy and diet do not account for these changes. The data support the hypothesis that LNH is a significant pathological finding in ASD children.
http://www.ncbi.nlm.nih.gov/pubmed/...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

There is a unique pattern of peripheral blood and mucosal CD3+ lymphocytes intracellular cytokines, which is consistent with significant immune dysregulation, in this ASD cohort.
http://www.ncbi.nlm.nih.gov/pubmed/...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
 
As I said, he does seem to be rather obsessional about this particular pathological entity.

The hypothesis that he ascribes to is one where MMR causes persisting infection, which causes inflammation in the colon. This allows putative "neurotoxins" to be absorbed, causing autism by some unclear mechanism.

He has looked at plenty of kids with bowel symptoms and autism. Why were these conditions "associated", he asked himself? He plucked the idea of MMR as a cause because he was told by parents that they thought vaccine was a factor. He looked for measles in the gut of these kids, and hey presto there it was. The rest is history.

Unfortunately for him, it has been shown that not only has the measles link not been replicated, but it was never there in the first place. He ignored evidence that the techniques he was using were unable to establish with any certainty whether virus was present, and the lab workers who did the assays testified to this effect, and studies using appropriate technology to detect virus have drawn a blank.

There may be some merit in pursuing a connection between bowel disease and autism, but not in trying to blame MMR for it.



http://www.ncbi.nlm.nih.gov/pubmed/...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Our review of the published works, nearly all from a single centre, identifies major inconsistencies between studies, lack of appropriate controls and misinterpretation of normal findings as pathology. Ileal lymphoid hyperplasia may be more prevalent in children with regressive autism but is also seen in children with food allergies and severe constipation, the latter being an extremely common finding in autistic children. CONCLUSION: The histopathological diagnosis of autistic enterocolitis should be treated with caution until a proper study with appropriate methodology and controls is undertaken.
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So does MDC stand for:

Mothering dot commune?
Marquis de Carabas?
Million Dollar Challenge?
 
Archives of Disease in Childhood

(It is part of bmj.com, The BMJ is published by BMJ Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association.)
 
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Yes.
In the thread's context i knew MDC stood for mothering dot commune.
However, it stuck me that here it could also be interpreted in other ways.
 
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