ddt
Mafia Penguin
Thanks. I'll await one or two more reactions before I submit my reaction to the CMAJ.Yes, by all means, it's quite factual and understandable.
Link to the paper
My (draft) reaction:
The authors conclude from their study that uncircumcised boys have a higher risk for urinary tract infection than circumcised boys. However, the study is fatally flawed and does not support this conclusion.
The authors have selected their test subjects from those boys that were referred to their hospital by primary and secondary health care providers, specifically with the request for a catheter urine culture. The test subjects are therefore not representative of the general population; at best, they are representative of those boys whom their physicians already suspect of having a urinary tract infection.
The collection of test subjects thus exhibits a selection bias compared to the general population, and thus no conclusions with respect to the general population can be drawn. The remarks in the "Strengths and limitations" section do nothing to substantially address this fundamental bias. Only a randomly drawn, representative, and sufficiently large sample of the general population can address the question of the comparison of UTI incidence between circumcised and uncircumcised.
Provided the sample is representative of all boys referred to the hospital with the request for catheter urine culture, conclusions can be drawn, however, with respect to the treatment of urinary tract infections.
1) First and second line physicians are better able to identify urinary tract infections and distinguish them from other conditions with uncircumcised boys than with circumcised boys: 1 in 4 uncircumcised boys referred to the Children's Hospital with the suspicion of a UTI actually have one, while only 1 in 20 circumcised boys have one. Thus, with circumcised boys, 5 times the effort has to be spent to identify one UTI.
2) Thus, circumcision leads to waste of the limited funds of Medicare Canada, i.e., public funds paid by the taxpayer, which has to pay for the catheter urine culture, the tests and the time of third line specialists.