jaydeehess
Penultimate Amazing
Actually substances in the blood stream that the body finds need to get rid of can take one or both of two routes.
One path is filtering by the glomuari in the kidneys and passing into the urine.
The other route is metabolism in the liver and having byproducts pass along the bile duct to the small intestine
Some things go both ways, caffine for eg is metabolised in the liver but byproducts largely pass back into the blood then are excreted in urine.
Tetracycline is excreted directly in the urine to a small extent but mostly is handled by the liver and passed into the intestines.
However if a substance causes problems with the small intestine or colon one could also expect liver issues and perhaps problems along the biliary tract including the spleen
Substances that are excreted in the urine and are toxic usually cause renal issues For eg tetracycline that is past its "due date" is known to cause Franconi syndrome which selectively causes the nephrons of the kidney to basically plug up and stop allowing reuptake of such things as water, glucose, and potassium back into the bloodstream from the filtrate coming from the glomuari
Alcohol has little effect on the GI tract but can kill the liver which is responsible for turning it back into sugar(despite the fact that the liver is a rarety in that it can regrow damaged tissue, as can the intestinal linings)
Unfortunately no kidney tissue ever can regenerate as far as I know.
Diseases that medsci has no idea as to the cause, i can think of one right off the bat; monoclonal gammopathy.
This is the cloning of whole immunoglobulins and often light chain proteins which go into immunoglobulin creation. These serve no function but do cause problems by building up into amyloid plaques that can block organ function. (and is a precursor to multiple myeloma and a form of luekemia) There is no definitive cause for most cases
I don't think there is a known reason why multiple scerlosis is more common in colder climates either
Odd thing is that there are a multitude of known viral causes of disease and a great deal of medsci research as to the immune system response to many of them which allows that benign versions of viruses or just the surface proteins of them to cause exactly the same immune response as the live virus. An immune system can then be, insome cases, primed for rapid and overwhelming reponse should it be subject to the live virus
One path is filtering by the glomuari in the kidneys and passing into the urine.
The other route is metabolism in the liver and having byproducts pass along the bile duct to the small intestine
Some things go both ways, caffine for eg is metabolised in the liver but byproducts largely pass back into the blood then are excreted in urine.
Tetracycline is excreted directly in the urine to a small extent but mostly is handled by the liver and passed into the intestines.
However if a substance causes problems with the small intestine or colon one could also expect liver issues and perhaps problems along the biliary tract including the spleen
Substances that are excreted in the urine and are toxic usually cause renal issues For eg tetracycline that is past its "due date" is known to cause Franconi syndrome which selectively causes the nephrons of the kidney to basically plug up and stop allowing reuptake of such things as water, glucose, and potassium back into the bloodstream from the filtrate coming from the glomuari
Alcohol has little effect on the GI tract but can kill the liver which is responsible for turning it back into sugar(despite the fact that the liver is a rarety in that it can regrow damaged tissue, as can the intestinal linings)
Unfortunately no kidney tissue ever can regenerate as far as I know.
Diseases that medsci has no idea as to the cause, i can think of one right off the bat; monoclonal gammopathy.
This is the cloning of whole immunoglobulins and often light chain proteins which go into immunoglobulin creation. These serve no function but do cause problems by building up into amyloid plaques that can block organ function. (and is a precursor to multiple myeloma and a form of luekemia) There is no definitive cause for most cases
I don't think there is a known reason why multiple scerlosis is more common in colder climates either
Odd thing is that there are a multitude of known viral causes of disease and a great deal of medsci research as to the immune system response to many of them which allows that benign versions of viruses or just the surface proteins of them to cause exactly the same immune response as the live virus. An immune system can then be, insome cases, primed for rapid and overwhelming reponse should it be subject to the live virus
