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Insulin Resistance-Possible Explaination?

Kumar

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Oct 13, 2003
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Hello all,

Diabetes may start in the intestines, research suggests
"Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes — may begin in the intestines"
https://news.wustl.edu/news/Pages/23409.aspx

Above is new research article. Many other sites suggest inflammation link with Insulin resistance. If so;

1. Whether persisting high blood glucose(BG) levels are attributed to inflammation/infection oriented chronically stimulation of SNS(sympathetic nervous system--fight or flight response)? If yes, whether developing neuropathy/dysatonomia control BG levels?

2. Whether anti inflammatory/antimicrobials help to control BG levels?

3. How GUT environment is related to BG levels?

Best wishes.
 
Many many variations in studies(somewhat daily change/new) are there about Insulin Resistance & Diabities. How & which to base???
 
Kumar said:
1. Whether persisting high blood glucose(BG) levels are attributed to inflammation/infection oriented chronically stimulation of SNS(sympathetic nervous system--fight or flight response)? If yes, whether developing neuropathy/dysatonomia control BG levels?
Best wishes.
Click to expand...

There was another study recently that showed that rats kept under stress more or less stopped growing.

It occurred to me then that it's possible that stress (which leads to abdominal fat depositing and thus to insulin resistance) may all be tied up in one big ball of wax caused by stress that stops the body from...what? Storing fat normally because you might suddenly need the energy? Hence the insulin resistance which then causes fat to be stored in the belly, bypassing this process.



Sounds like what is needed is a drug (alcohol, anyone?) that eliminates stress, or at least short-circuits it's fight-or-flight-inducing biochemistry.
 
Yeah, it starts in the intestines alright. It's called 'over-eating'.

Be wary of clever scientists trying to create elaborate theories to explain simple things. Sometimes they're right. A lot of times it's just the smoke, not the fire.

~Dr. Imago
 
Kumar said:
Many many variations in studies(somewhat daily change/new) are there about Insulin Resistance & Diabities. How & which to base???
Click to expand...

A good place to start is to read it. From this newsy article all they found is that lack of Fatty Acid Synthetase leads to inflammation in the gut, it doesn't match the headline although they do include the 'may' weasel word.
 
Let us check the possibilties:-

Digestion, absorption & intestinal lining can be effected by abnormal acidic condition, thinning of intestinal mucus coating, losing protective fats in lining.

Let us check; bile defficiency which may cause abnormal acidic condition in intestines, lesser fats absorption(which may effect protective fats. It should be possible that people showing lower Cholesterl lower TG levels, should be having lower bile secretion effecting intestinal pH, lesser fats absorption, other?,. I think low bile is related to getting constipation/unclear motions & distention.
 
Acleron said:
A good place to start is to read it. From this newsy article all they found is that lack of Fatty Acid Synthetase leads to inflammation in the gut, it doesn't match the headline although they do include the 'may' weasel word.
Click to expand...

"May" may be common in most research. But it looks quite logical that losing protective coats, thinning mucus, abnormal acidic condition may cause damage to intestinal lining, pathogens to move in lining(leaky GUT).

It should also be possible that, whichever nutients are in excess in body or not required, esp. those which do not have efficient excretory mechnism(eg. fats, iron etc.) are controlled by altering intestinal mechanism--digestion & absorption. Whether such alteration is mechenical, chemical or inflammatory(lipid peroxidation) is need to be understood.
 
I think figuring out the connection between our lost parasites (whipworms, bacteria, etc.) and autoimmune diseases will be the biggest advance in medicine since the discovery of antibiotics.

Rewilding the gut doesn't seem to me to be a reasonable answer. We'll have to artificially recreate the effects of the things we artificially killed in the first place.
 
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Dr. Imago said:
Yeah, it starts in the intestines alright. It's called 'over-eating'.

Be wary of clever scientists trying to create elaborate theories to explain simple things. Sometimes they're right. A lot of times it's just the smoke, not the fire.

~Dr. Imago
Click to expand...
It's more along the line of eating the wrong unhealthy things, than over eating, if you're going to simplify the issue to this level.
 
Halfcentaur said:
It's more along the line of eating the wrong unhealthy things, than over eating, if you're going to simplify the issue to this level.
Click to expand...

Whatever odd which our body mechanism can't process naturally pre-informed, or whatever excess to us esp those which do not have effecienct excretery system can trigger defence, inflammatory & immune mechanisms. Obiously odds/toxic eatings can be more dangerous but toxic can also suggest excess.
 
Kumar said:
Whatever odd which our body mechanism can't process naturally pre-informed, or whatever excess to us esp those which do not have effecienct excretery system can trigger defence, inflammatory & immune mechanisms. Obiously odds/toxic eatings can be more dangerous but toxic can also suggest excess.
Click to expand...

What does 'naturally pre-informed' mean?
What do you refer to with 'those which do not have effecienct excretery system'?
What are you talking about here? 'Obiously odds/toxic eatings can be more dangerous'

Please write your posts in standard English.
 
pakeha said:
What does 'naturally pre-informed' mean?
What do you refer to with 'those which do not have effecienct excretery system'?
What are you talking about here? 'Obiously odds/toxic eatings can be more dangerous'

Please write your posts in standard English.
Click to expand...

'naturally pre-informed': To which we have inharent sense of right & wrong.
I think iron, fats etc. do not have efficient excretery system after their absorpion into the body.

Toxicity can be dependent of quantity may not be quality since single minimum quantity of any sustance may not be harmful to bodies.

Pls try to manage with my language.
 
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