Skeptic_Ginger -
If you're really going to try for manned interstellar travel via nuclear pulse propulsion, and you care about getting the numbers right, I suggest that you need to do some research. The numbers involved are pretty mind-boggling. For a start, try
http://en.wikipedia.org/wiki/Project_Orion_(nuclear_propulsion)#Economics.
A few basic principles:
1) These things are huge. One way to look at it is that you need nukes for fuel/energy efficiency, and nukes have big bangs. This in turn means you need big shock absorbers to keep the explosion impulse from crushing the passengers, and there are severe material limits to what you can do. Note that this means you can't do small ships, and what you can do (barring specifying von Neumann robots) will be fabulously expensive.
2) These things take an enormous number of nukes. Put it this way, to get to 0.1c at 4 g's takes about 750,000 seconds. If you get this by dropping one bomb per second, well, that's a whole lot of bombs. And having a stockpile of 3/4 of a million nukes in orbit around the earth would seem to suggest all sorts of plot twists.
3) If you want to specify unobtainium plated with handwavium, you can make all sorts of ameliorating suggestions, but you need to think them through.
Best of luck.