Part of the confusion is that HFCS isn't just one formula.
Sucrose, as has been pointed out, is a
disaccharide, a molecular compound made up of two different
monosaccharides, one molecule each of glucose and fructose, which means that
pure sucrose by definition is 50/50.
Table sugar, by convention (but not necessarily by definition) is mostly sucrose.
HFCS is a
mixture of (mostly) glucose and fructose, not a compound, and depending on the intended purpose the proportions are different.
From Wiki.
This is what jt512 was referring to.
The main point is that once it hits your tummy it doesn't matter any more. Your stomach acids convert the sucrose to its component sugars anyway, and then your body goes on to process them as if they had never been a compound.
For all practical purposes it just doesn't make any difference how the sugars are bonded (or not). What is important is the total intake.
The real issue with HFCS is an economic one. It's
cheap, and that makes it easier for a manufacturer to add to a prepared food. Our bodies are evolved to like sugar, and sweetening makes a food more attractive. That is an irresistible sales gimmick.
HFCS alarmists are missing the point, either through ignorance or neglect. Which
kind of sugar isn't the problem. If it was then apples and pears would be at the top of the hit list. Their fructose to glucose ratio is around 2:1. It's
how much sugar is getting into our diet that is the problem.