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Survival

Complexity said:
And yet you remain so ignorant of the subject.

I've got Type 2 Diabetes and really resent your deliberate dissemination of incorrect information on the subject.

You are merely a homeopathy woo trolling on a skeptics' forum.

Shame on you.
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You can read it;-

Receptor downregulation
[edit] Mechanism
The process of downregulation occurs when there are elevated levels of the hormone insulin in the blood. When insulin binds to its receptors on the surface of a cell, the hormone receptor complex undergoes endocytosis and is subsequently attacked by intracellular lysosomal enzymes. The internalization of the insulin molecules provides a pathway for degradation of the hormone as well as for regulation of the number of sites that are available for binding on the cell’s surface without doubts. At high plasma concentrations, the number of surface receptors for insulin is gradually reduced by the accelerated rate of receptor internalization and degradation brought about by increased hormonal binding. The rate of synthesis of new receptors within the endoplasmic reticulum and their insertion in the plasma membrane do not keep pace with their rate of destruction. Over time, this self-induced loss of target cell receptors for insulin reduces the target cell’s sensitivity to the elevated hormone concentration. The process of decreasing the number of receptor sites is virtually the same for all hormones; it varies only in the receptor hormone complex.

[edit] Cases
This process is illustrated by the insulin receptor sites on target cells in a person with type 2 diabetes. Due to the elevated levels of blood glucose in an overweight individual, the β-cells (islets of Langerhans) in the pancreas must release more insulin than normal to meet the demand and return the blood to homeostatic levels. The near-constant increase in blood insulin levels results from an effort to match the increase in blood glucose, which will cause receptor sites on the liver cells to downregulate and decrease the number of receptors for insulin, increasing the subject’s resistance by decreasing sensitivity to this hormone. There is also a hepatic decrease in sensitivity to insulin. This can be seen in the continuing gluconeogenesis in the liver even when blood glucose levels are elevated. This is the more common process of insulin resistance, which leads to adult-onset diabetes.

[edit] Reversal
The process of downregulation can be counteracted in the above example. A person with type 2 diabetes can increase their sensitivity to insulin through proper diet and regular exercise, resulting in weight loss; some individuals may even return to their pre-diabetic state by following such a regimen.
http://en.wikipedia.org/wiki/Downregulation_and_upregulation
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Kumar.
What the hell are even attempting to communicate?
Nobody understands you.
 
Kumar said:
You don't believe or believe in concentrated chemical agents(which may not need placebo effect) there should be missing benefits from belief or placebo effects..
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What makes you think that people don't believe real medicines work?
 
Is it just me, or is he becoming more incoherent as summer progresses?

Kumar, do you have air-conditioning? You may be suffering from prolonged heat stroke.
 
Mojo said:
What makes you think that people don't believe real medicines work?
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If they believe, their basis can be believing on half cooked things which are not yet absolute & final and which have potential to give side/adverse effects.

In real sense, I should be considered biggest skeptic because I have chronic doubting & questioning habit till a thing become A&F esp. on those which can give adversities. Not so??

However, I am not skepting on yet unclear things which exist in people at mass with least advesities and even remain curious to know their science/logic even these are placebo. I do care for odds & suggest to be bit precautionary and avoid blind faith while following unclear things--in CAMs or CMs. As I feel there should be some goods in everything(God is said to be omnipresent) I do respect goods of everything/knowledge--CAMs, CMs or otherwise.

I hope I have cleared my status in simple & clear words, should be truthful, so need not to be doubted or impressed again & again. Best wishes.
 
Kumar said:
If they believe, their basis can be believing on half cooked things which are not yet absolute & final and which have potential to give side/adverse effects.
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No.

In real sense, I should be considered biggest skeptic because I have chronic doubting & questioning habit till a thing become A&F esp. on those which can give adversities. Not so??
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Definitely not so.

However, I am not skepting on yet unclear things which exist in people at mass with least advesities and even remain curious to know their science/logic even these are placebo. I do care for odds & suggest to be bit precautionary and avoid blind faith while following unclear things--in CAMs or CMs. As I feel there should be some goods in everything(God is said to be omnipresent) I do respect goods of everything/knowledge--CAMs, CMs or otherwise.
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No.
 
Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels.
Y Okabayashi, B A Maddux, A R McDonald, C D Logsdon, J A Williams and I D Goldfine
+ Author Affiliations

Cell Biology Laboratory, Mount Zion Hospital, San Francisco, California 94120.
Abstract
The influence of insulin on the downregulation of its receptor was studied in AR42J cultured pancreatic acinar cells, a cell line that has been demonstrated to be metabolically responsive to insulin..... Therefore, these studies indicate that insulin may diminish the concentration of its receptors in target cells by at least two mechanisms: acceleration of receptor degradation and inhibition of receptor biosynthesis at the level of mRNA.
http://diabetes.diabetesjournals.org/content/38/2/182
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The above understanding is from American Diabetic Association desk.
 
Jesus Christ. Head, wall, meet.

Kumar said:
If they believe, their basis can be believing on half cooked things which are not yet absolute & final and which have potential to give side/adverse effects.
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NOTHING CAN BE ABSOLUTE AND FINAL.

In real sense, I should be considered biggest skeptic because I have chronic doubting & questioning habit till a thing become A&F esp. on those which can give adversities. Not so??
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No. NOTHING CAN BE ABSOLUTE AND FINAL.

However, I am not skepting on yet unclear things which exist in people at mass with least advesities and even remain curious to know their science/logic even these are placebo. I do care for odds & suggest to be bit precautionary and avoid blind faith while following unclear things--in CAMs or CMs. As I feel there should be some goods in everything(God is said to be omnipresent) I do respect goods of everything/knowledge--CAMs, CMs or otherwise.
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No. What people believe is irrelevant to what is true. Whether there are adverse effects is irrelevant to the efficacy of treatment. NOTHING CAN BE ABSOLUTE AND FINAL.

I hope I have cleared my status in simple & clear words, should be truthful, so need not to be doubted or impressed again & again. Best wishes.
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All you have cleared is that you do not read, listen, comprehend, or accept anything we have ever told you. You are delusional. You are in your own little world, and nothing we can say can show you that you are wrong, even when you are.

You should stick to religion and not science.
 
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