As a purely intellectual exercise, what would it take to move the International Space Station into a Lunar orbit? Could this be done?
No. For control reasons if nothing else.
Would the station be able to withstand the rigors of accelerating to an escape velocity and then decelerating to enter Lunar orbit?
There are some remarkably low thrust orbital designs out there these days. It would take a long time to get there, but I'm sure a transfer orbit could be found that would preserve the structure.
Getting the propulsion up there to move it, however, would be no picnic. Delta-V from LEO to LTO is about 4 km/s, times 400 tons station mass, is a heck of a lot of total impulse. Electric would be the way to do it, but even so you're talking about a lot of upmass to make it move.
Would there be adequate shielding to protect inhabitants once there?
No. Astronauts would be vulnerable to solar weather, just like they were in the Apollo program. However, if we're shipping up many many tons of thruster, we could also ship a radiation shelter, I suppose.
Could it be used as a refueling and refitting waystation for some craft like the DC-X to make repeated trips to the Lunar Surface? Is there any merit to the idea from either a scientific or economic standpoint?
The ISS is not currently equipped to handle fuels. In general, the idea is feasible, though the current architecture would probably be cost-prohibitive to retrofit under any scenario.
In case you're wondering I was talking to a friend about possible unorthodox means of exploring the Moon should Obama and Congress decided to gut the Constellation Program and this just came up.
I assume you've read the
Augustine Commission Report? It treats exactly this kind of question in detail, albeit one with its own strong opinions and biases.
The ISS is and has been useful in its own right, among other things to teach us how to build and manage large structures in space. It's an enormous problem all its own. If you've ever let your garage get cluttered or had a hard time editing your software registry, you can probably appreciate how stupendously difficult this kind of enterprise really is. However, for lunar expeditions, it isn't clear how valuable ISS would be -- that's not what it was designed for. It certainly gives us some possible abort / lifeboat modes in case of off-nominal crew launches from Earthside, but once outside LEO it's just another point of light.
Disclaimer, all opinions are mine alone and do not represent NASA or any other agency in any way; also it's all off the top of my head.