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New antiquack blog

Incredible New Blog

This is going to be a really great new blog. Some of the best minds in medical skepticism are involved - and me. I'm not one of the best minds, and I'm wondering if they needed a token female or wanted some comic relief. Whatever the reason, I am tickled pink to be in their company, and I will do my best to inform and entertain. There are 5 regular authors, each doing one day a week. The other regulars are Steve Novella (of Skeptics Guide to the Universe podcast fame), Wallace Sampson (editor of Scientific Review of Alternative Medicine), Kimball Atwood, and David Gorski. And there will be guest authors too. These are really smart guys and will help keep each other straight and guarantee that the blog is a reliable source of trustworthy information and critical thinking.

I'll be posting every Tuesday. Some of my upcoming topics: a lengthy book review of "Snake Oil Medicine," the no-touch chiropractor, and my surreal experience trying to get the "published evidence" that a weight loss supplement company advertised (I knew it existed because their ad says "we couldn't say it in print if it wasn't true"). :)
 
Excellent Series on Homeopathy

Today's blog entry begins a series on homeopathy. Well worth a look. Reveals some things even I didn't know!
 
So far this site is unimpressive and belies the ignorance of the blog owner more than anything else. Here is my response to the key argument, around the "The Plant vs Pharmaceutical False Dichotomy":

“First and foremost, herbs and plants that are used for medicinal purposes are drugs - they are as much drugs as any manufactured pharmaceutical. A drug is any chemical or combination of chemicals that has biological activity within the body above and beyond their purely nutritional value. Herbs have little to no nutritional value, but they do contain various chemicals, some with biological activity. Herbs are drugs. The distinction between herbs and pharmaceuticals is therefore a false dichotomy.”

This is a failure of an argument, due to faulty logic and woeful ignorance. Please don’t pretend to have an informed opinion where there is none. There are many, many examples of herbs that can be used medicinally but are also used as food or food additives. For example, Ginger (Zingiber officinalis) is clearly used as a food, and yet also has both credible scientific not to mention an enormous body of empirical evidence. On PubMed I brought up 777 citations simple by searching “Zingiber officinalis OR ginger”, 57 of which were human _clinical_ trials. And yet, by your logic, you are telling me that because I like my Indian food rich with the zesty taste of ginger that I am eating a drug? Hogwash!!

Other similar examples that come to mind include Garlic (Allium sativum), Alfalfa (Medicago sativa), Nettle (Urtica dioica), Oats (Avena sativa), Calendula (Calendula officinalis), Gotu Kola (Centella asiatica), Damiana (Turnera diffusa), Huang qi (Astragalus membranaceus), Wu wei zi (Schizandra chinensis), and Amalaki (Phyllanthus emblica). All of these herbs have research trials to back up their use and yet also have a long history as medicinal foods. In this list we could also include culinary herbs, such as basil, bay, oregano, cumin, asafoetida, cinnamon, pepper, allspice etc etc, which are also used as both medicines and foods.

If you are unconvinced of their medicinal effects that is one thing (which again speaks to your woeful ignorance) but the fact remains that the vast majority of these herbs are listed in at least one official pharmacopeia, in countries such as Canada, Germany, India and China. The fact that they do not contribute significant amounts of calories is besides the point because there are several examples of low calories foods, such as above ground leafy green vegetables. Herbs ARE NOT drugs. Your are WRONG! Just look at how hey are regulated in places like Canada, where they are officially recognized as “natural health products”: neither food NOR drug.
 
Ok, while I'm on a rant, let me take this opportunity to correct a few misconceptions, etymological and otherwise. Number one, the origin of the word "quack", which is typically applied to the field of alternative medicine, in actuality referred to the "quack" doctors who used "quack" or "quicksilver", which was the treatment of choice in modern medicine for about 250 years prior to the discovery of penicillin. That and bloodletting, as well as the use drastic purging agents such as Gamboge and the use of opiates.

Over this period, countless numbers of people were poisoned and many died from receiving these sanctioned albeit "quack" treatments, and in the early 1800's, it was the outrage of these standard practices that in large part stimulated the field of "alternative" medicine. If you are interested to do any research in this area, I suggest reading "Kindly Medicine: Physio-Medicalism in America, 1836-1911" and "The People's Doctor: Samuel Thomson and the American Botanical Movement 1790-1860", both by John S. Haller, or as a lighter read, Barbara Griggs' "Green Pharmacy".

The great irony is that today the medicos attempt to insult CAM practitioners with a label that speaks directly to their _own_ history, and today replicates itself in the use of pharmaceuticals that are now considered (by conservative estimate) to be _at least_ the #3 causes of death among americans (see: Starfield, B. 2000. Is US Health Really the Best in the World? JAMA. 284:4, 483). The pot calling the kettle black indeed!

Secondly, "snake oil" was in common use in North America during the 1800's, mostly sold by oriental practitioners for whom it has a long history of traditional use. Although derided as "quack" remedy, when we compare it to the extremely toxic "quacksilver" (as mercurous chloride) similarly in use at the time, snake oil hardly seems worthy of such derision. From Wikipedia, under "snake oil":

"Snake oil sold in San Francisco's Chinatown in 1989 was found to contain:
• 75% unidentified carrier material, including camphor
• 25% oil from Chinese water snakes, itself consisting of:
• 20% eicosapentaenic acid (EPA) - an omega 3 derivative
• 48% myristic acid (14:0)
• 10% stearic acid (18:0)
• 14% oleic acid (18:1w9)
• 7% linoleic acid (18:2w6) plus arachidonic acid (20:4w6)

The Chinese water snake (Enhydris chinensis) is the richest known source of EPA, the starting material the body uses to make the series 3 prostaglandins. These prostaglandins are the biochemical messengers which control some aspects of inflammation, rather like aspirin which also affects the prostaglandin system. Like essential fatty acids, EPA can be absorbed through the skin. Salmon oil, the next best source, contains 18% EPA. Rattlesnake oil contains 8.5% EPA."

At the very least, one could attribute a medicinal effect to the exceptionally high EPA content of snake, which according to dietary research, is an important factor in the maintenance of health. Considering that most americans consume far too much omega 6 relative to omega 3 fatty acids (estimated to be between 17:1 or higher), and that our paleolithic ancestors with which we share 99.9% the same genome consumed a ratio closer to 2:1 (n6:n3), a great deal of people nowadays would benefit from regularly consuming snake oil. Especially those of you with big prediabetic bellies that spend too much time on this site deriding things you know very little about.
 
So far this site is unimpressive and belies the ignorance of the blog owner more than anything else. Here is my response to the key argument, around the "The Plant vs Pharmaceutical False Dichotomy":

“First and foremost, herbs and plants that are used for medicinal purposes are drugs - they are as much drugs as any manufactured pharmaceutical. A drug is any chemical or combination of chemicals that has biological activity within the body above and beyond their purely nutritional value. Herbs have little to no nutritional value, but they do contain various chemicals, some with biological activity. Herbs are drugs. The distinction between herbs and pharmaceuticals is therefore a false dichotomy.”

This is a failure of an argument, due to faulty logic and woeful ignorance. Please don’t pretend to have an informed opinion where there is none. There are many, many examples of herbs that can be used medicinally but are also used as food or food additives. For example, Ginger (Zingiber officinalis) is clearly used as a food, and yet also has both credible scientific not to mention an enormous body of empirical evidence. On PubMed I brought up 777 citations simple by searching “Zingiber officinalis OR ginger”, 57 of which were human _clinical_ trials. And yet, by your logic, you are telling me that because I like my Indian food rich with the zesty taste of ginger that I am eating a drug? Hogwash!!

Other similar examples that come to mind include Garlic (Allium sativum), Alfalfa (Medicago sativa), Nettle (Urtica dioica), Oats (Avena sativa), Calendula (Calendula officinalis), Gotu Kola (Centella asiatica), Damiana (Turnera diffusa), Huang qi (Astragalus membranaceus), Wu wei zi (Schizandra chinensis), and Amalaki (Phyllanthus emblica). All of these herbs have research trials to back up their use and yet also have a long history as medicinal foods. In this list we could also include culinary herbs, such as basil, bay, oregano, cumin, asafoetida, cinnamon, pepper, allspice etc etc, which are also used as both medicines and foods.

If you are unconvinced of their medicinal effects that is one thing (which again speaks to your woeful ignorance) but the fact remains that the vast majority of these herbs are listed in at least one official pharmacopeia, in countries such as Canada, Germany, India and China. The fact that they do not contribute significant amounts of calories is besides the point because there are several examples of low calories foods, such as above ground leafy green vegetables. Herbs ARE NOT drugs. Your are WRONG! Just look at how hey are regulated in places like Canada, where they are officially recognized as “natural health products”: neither food NOR drug.

Is it possible that you simply misunderstood the intent behind the distinction that was being made?

Linda
 
Ok, while I'm on a rant, let me take this opportunity to correct a few misconceptions, etymological and otherwise. Number one, the origin of the word "quack", which is typically applied to the field of alternative medicine, in actuality referred to the "quack" doctors who used "quack" or "quicksilver", which was the treatment of choice in modern medicine for about 250 years prior to the discovery of penicillin. That and bloodletting, as well as the use drastic purging agents such as Gamboge and the use of opiates.

Over this period, countless numbers of people were poisoned and many died from receiving these sanctioned albeit "quack" treatments, and in the early 1800's, it was the outrage of these standard practices that in large part stimulated the field of "alternative" medicine. If you are interested to do any research in this area, I suggest reading "Kindly Medicine: Physio-Medicalism in America, 1836-1911" and "The People's Doctor: Samuel Thomson and the American Botanical Movement 1790-1860", both by John S. Haller, or as a lighter read, Barbara Griggs' "Green Pharmacy".

When we refer to quack treatments/practitioners, the distinction isn't between whether or not any of them were part of standard practice, but rather what kind of methods and information are used to guide their practice. The quack physicians of the past and present are those who are satisfied with not knowing whether or not they are wrong and that depend upon the use of unreliable information (observation in the absence of blinding or controls, subjective perceptions instead of objective evaluations, hypothesizing on the basis of analogy or untested ideas, etc.). I agree that much of standard medical practice (when it comes to treatment, anyway) prior to the application of the scientific method would now qualify as quackery. You will notice that those treatments are no longer used, though.

The great irony is that today the medicos attempt to insult CAM practitioners with a label that speaks directly to their _own_ history, and today replicates itself in the use of pharmaceuticals that are now considered (by conservative estimate) to be _at least_ the #3 causes of death among americans (see: Starfield, B. 2000. Is US Health Really the Best in the World? JAMA. 284:4, 483). The pot calling the kettle black indeed!

That statement is incorrect. The estimated deaths from adverse drug reactions from that particular article (106,000) would place it at the 5th leading cause of death (or about 4%) for that year.

However, what is misleading about your statement, is that even taking these deaths into account, the total death is much lower because of the use of pharmaceuticals. The majority of deaths from adverse drug reactions are not preventable. I explain this a bit here.

Linda
 
So far this site is unimpressive and belies the ignorance of the blog owner more than anything else. Here is my response to the key argument, around the "The Plant vs Pharmaceutical False Dichotomy":

“First and foremost, herbs and plants that are used for medicinal purposes are drugs - they are as much drugs as any manufactured pharmaceutical. A drug is any chemical or combination of chemicals that has biological activity within the body above and beyond their purely nutritional value. Herbs have little to no nutritional value, but they do contain various chemicals, some with biological activity. Herbs are drugs. The distinction between herbs and pharmaceuticals is therefore a false dichotomy.”

This is a failure of an argument, due to faulty logic and woeful ignorance. Please don’t pretend to have an informed opinion where there is none. There are many, many examples of herbs that can be used medicinally but are also used as food or food additives. For example, Ginger (Zingiber officinalis) is clearly used as a food, and yet also has both credible scientific not to mention an enormous body of empirical evidence. On PubMed I brought up 777 citations simple by searching “Zingiber officinalis OR ginger”, 57 of which were human _clinical_ trials. And yet, by your logic, you are telling me that because I like my Indian food rich with the zesty taste of ginger that I am eating a drug? Hogwash!!

Other similar examples that come to mind include Garlic (Allium sativum), Alfalfa (Medicago sativa), Nettle (Urtica dioica), Oats (Avena sativa), Calendula (Calendula officinalis), Gotu Kola (Centella asiatica), Damiana (Turnera diffusa), Huang qi (Astragalus membranaceus), Wu wei zi (Schizandra chinensis), and Amalaki (Phyllanthus emblica). All of these herbs have research trials to back up their use and yet also have a long history as medicinal foods. In this list we could also include culinary herbs, such as basil, bay, oregano, cumin, asafoetida, cinnamon, pepper, allspice etc etc, which are also used as both medicines and foods.

If you are unconvinced of their medicinal effects that is one thing (which again speaks to your woeful ignorance) but the fact remains that the vast majority of these herbs are listed in at least one official pharmacopeia, in countries such as Canada, Germany, India and China. The fact that they do not contribute significant amounts of calories is besides the point because there are several examples of low calories foods, such as above ground leafy green vegetables. Herbs ARE NOT drugs. Your are WRONG! Just look at how hey are regulated in places like Canada, where they are officially recognized as “natural health products”: neither food NOR drug.

That makes no sense. The quote you are attacking didn't say herbs aren't treated as food, it said they are pharmaceuticals . Of course something can be used as food and contain pharmaceuticals.
 
Apparently my capacity to add further comments to the "Science-based medicine" blog have been disabled (so much for rational debate!), and so I post his/her comments, followed by mine:

You are confusing “having nutritional value” with “used as food.” I never said herbs were not used as food or in food, just that when they are taken as medicinals the doses used have negligible nutrition, but do contain possible biologically active doses of drugs. (Incidentally, it is also possible to use herbs to add flavor to food while still adding negligible nutritional value.)

Also - using as a food and taking as a drug are not mutually exclusive, as you suggest. Many people drink coffee as a beverage, but they are definitely dosing themselves with caffeine, which is unquestionably a drug.

The real and only question is - what is causing a potential biological response? Is it calories, vitamins, minerals, and building blocks (food), or is it chemicals that have pharmacological activity (drugs)?

I also never said that medicinal plants are not potentially useful or are without effects or benefits. I simply think they need to be properly studied and regulated.

Your argument that herbs are food because they are regulated as foods in some countries is not valid. It is based upon the false assumption that regulations must be rational or science-based - often they are not. Scientific conclusions are not based upon existing regulations - regulations should be based upon scientific conclusions, but often are not.

In fact, one of the points of my article is that plant-based medicinals should be regulated as drugs and not as food or even supplements. However, the question of regulation is a complex one and was not the primary focus of my article, so I did not explore all of the nuances of this topic."

and my comments:

You clearly know little of the actual practice of herbal medicine, let alone the volumes of academic literature on the subject. The fact of the matter is that herbs transcend the narrow definitions of food or drug. A good example are the many medicinal food recipes used in both Chinese and Ayurvedic medicine, for example, to add to the functionality of foods such as broths. For example, in China, people have for thousands of years fortified soups with the use of medicinal herbs, such as Angelica sinensis, Lycium barbatum, Astragalus membranaceus, Panax ginseng and Paeonia lactiflora. These herbs are usually added in quantities that _far_ surpass the typical recommended dosage on dietary supplements sold in the USA.

Your argument that herbs do not add to the nutrient value was already addressed in my earlier post, which you seem to completely miss. What is a "nutrient"? Only a carb, protein or fat? Of course not, because you would be excluding vitamins, minerals and an entire host of accessory nutrients, many of which are being discovered as we speak. Even Wikipedia seems to know this differences: en(dot)wikipedia(dot)org/wiki/Nutrient. Thus your "nutrient" argument is false. Herbs contains nutrients and these nutrients support human metabolism.

To clarify, I have not said that herbs are necessarily food (although I have provided several examples already), but neither are they drugs, or at least "drugs" in the sense of being highly purified chemical extractives that have a very small therapeutic window, and hence, have a much greater capacity to cause adverse effects. If you survey the literature, you will find that the adverse effects attributed to the vast majority of herbs are comparable to foods, and nowhere close to drugs.

Herbal constituents are not drugs until removed from their biochemical milieu, isolated and purified many, many times beyond their natural occurrence. A select few "special" herbs such as cannabis, coffee, coca and the tropane alkaloid-containing nightshades (e.g. Hyocyamus) contain chemicals that exert drug-like properties, but all of these herbs in their own way, at some point in human history, have been added to or used as foods. However, it is important to note that the vast majority of herbs do not contain constituents that exert these "drug-like" properties - you cannot rationally tarnish the entire spectrum of herbal medicines because a few at the most extreme end of the spectrum have drug-like properties. To do so is irrational.

As such, while you lay claim to rationality, it is easy to see that your argument is NOT rational: it is based on a belief, a belief that "herbs are drugs". While you accuse others of creating a false dichotomy, in reality, it is you who does so by refusing to see the subtlety and nuance that can only come with a greater level of sophistication than you are clearly able to bring to the subject.

Once again, please do yourself a favor and gather a little more data and _experience_ before you feel yourself capable of pronouncing such silly judgments. If not for the herbs, at least for science itself. I worry when people like you who lack basic knowledge on the subject call for "regulation" (even when sound regulatory models exist, such as in Canada). In real terms, what you (perhaps unwittingly) propose is simply an affront to individual liberty, creating a tempest in teapot where none exists, with the only people to benefit being big pharma, who we all know would love to see herbs classified as drugs if not to enhance their own revenue, at the least, to do away with the competition.
 
Nope. It is disinformation by uniformed people that needs to be corrected. Herbs are NOT drugs. Period.
 
Vaidya has been effectively answered by Dr. Novella in the comments section of the blog. If he has been blocked from further comments it is probably because he uses insults like "woeful ignorance" and "false pride" rather than the kind of polite, productive discussion the blog encourages, and because he has misunderstood the article he is attacking, as Dr. Novella's response shows.
 
It does look like you are simply misunderstanding the point of what is meant by the term "drug".

In this context, a drug is simply something taken for medicinal rather than nutritive purposes (although, of course, it is possible for a substance to have both). It doesn't necessarily mean that it's purified or removed from its biochemical milieu, just that there is an expectation of a biological effect.

Linda
 
When we refer to quack treatments/practitioners, the distinction isn't between whether or not any of them were part of standard practice, but rather what kind of methods and information are used to guide their practice. The quack physicians of the past and present are those who are satisfied with not knowing whether or not they are wrong and that depend upon the use of unreliable information (observation in the absence of blinding or controls, subjective perceptions instead of objective evaluations, hypothesizing on the basis of analogy or untested ideas, etc.). I agree that much of standard medical practice (when it comes to treatment, anyway) prior to the application of the scientific method would now qualify as quackery. You will notice that those treatments are no longer used, though.

Take a close hard look at a drug pharmacopeia some time. You will find that for many drugs, the pharmacology is either poorly understood, simplistic or hypothetical. Now, add into this this mix a medical doctor's capacity to prescribe off label. All of this would hardly suggest a strong scientific basis. Often the use of these drugs are based on a prevailing theory that has a questionable basis, for e.g., that depression is caused by a relative serotonin deficiency, or that CVD is caused by high cholesterol. These are scientifically flawed paradigms that persist only because it is financially expedient. This in not good science.


That statement is incorrect. The estimated deaths from adverse drug reactions from that particular article (106,000) would place it at the 5th leading

thanks for the correction - what i failed to add is that this does not tell the whole story, since 106,000 deaths relates ONLY to hospitalized patients not given the wrong drug or the wrong dose

as reported by Lazarou (1998), the IOM (2000), and Starfield (2000), if we factor in out-patient deaths we need to add in another 199,000, and then if we want to add in physician error (which seems fair, after all, an argument can be made that most drugs are _inherently_ toxic), we should add in another 98,000 deaths

thus the total damage from drugs alone? 403,000 deaths annually in the United States, which makes it number three - and these are rather old data



However, what is misleading about your statement, is that even taking these deaths into account, the total death is much lower because of the use of pharmaceuticals. The majority of deaths from adverse drug reactions are not preventable.


this belief that we need to kill a certain portion of the population to save another is a false argument

i guess it is easy to be so casual with other people's lives when they are reduced to statistics

the fact is that this belief is wrong and misinformed - in my own practice i have successfull weaned many people off of health damaging pharmaceuticals, even drugs you might think _never_ could be removed such as digoxins (but that because you folks don't know about the non-cumulative cardiactive glycosides found in Convallaria majalis:))

we can do better than this, and there are models out there that demonstrate this if you choose to look

but in order to do this, medicine needs to challenge some very basic assumptions about its state of practice
 
Vaidya has been effectively answered by Dr. Novella in the comments section of the blog. If he has been blocked from further comments it is probably because he uses insults like "woeful ignorance" and "false pride" rather than the kind of polite, productive discussion the blog encourages, and because he has misunderstood the article he is attacking, as Dr. Novella's response shows.

then why don't you respond to my comments?

novella is not an informed person on the subject of herbal medicine, and clearly, neither are you
 
It does look like you are simply misunderstanding the point of what is meant by the term "drug".

In this context, a drug is simply something taken for medicinal rather than nutritive purposes (although, of course, it is possible for a substance to have both). It doesn't necessarily mean that it's purified or removed from its biochemical milieu, just that there is an expectation of a biological effect.

Linda

the term "drug" is a regulatory term, a kind "proprietary" term that denotes usage by a particular professional class, and so when you use it, you need to be aware of this

and in this context, herbs are not drugs
 
And welcome to the forum, Vaidya. :)

Linda

thank you!

as a side note, please don't mistake my passion for contempt

i have been in the field of herbal medicine for 15 years, and am author of several academic works on the subject, so i am not just crank
 
then why don't you respond to my comments?

novella is not an informed person on the subject of herbal medicine, and clearly, neither are you

Because Dr. Novella has already responded appropriately and because I do not think it is productive to enter a debate with someone who has already shown that he has misunderstood Dr. Novella's arguments and who has made up his mind that Dr. Novella and I are not informed.
 

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