"Fat" Gene Found by Scientists

What I would like to see people take from studies like this is not "Oh, those fatties, now they have another excuse to sit on the couch and eat everything they want." I would like to see something more like "Say, that's yet another factor making it more difficult for some people to lose body fat. Perhaps some of those fat people aren't sitting on the couch after all."

One other point: one thing that keeps people going on exercise and diet regimes is progress. If your personal progress is really slow, you have that much less feedback for figuring out whether your regime is working, and that much less success to help keep you inspired to keep hitting the gym and the salad.
 
But this is not new, yet the rate of obesity has risen sharply in the past two decades. It's not like we were in starvation mode back in the 70s.

No, we were not, though outside America, high calorie junk food formed a far smaller part of the diet than it does now.
To my mind, the major changes since the seventies are in exercise levels and dietary balance.

In the UK in the 1970s, most kids walked to school, played games which involved running or skipping and with the exception of an occasional meal of fish and chips, did not eat "fast food" at all.

I first encountered a McDonalds in Canada in 1979. I saw my first one in Britain about 1985.
Since the early 1980s, the shape of British children has changed dramatically. It seems pretty obvious that this is connected to change of diet and lack of exercise- particularly in early childhood.

Genetic variation obviously matters. It's clear some kids eat the same rubbish as others - sometimes more of it - and stay slim. How much of that is exercise, how much genetically controlled metabolism is an open question.
As of course- is how much is the tendency to take exercise genetic?
A kid with good hand/ eye coordination , strong bones, joints and muscles gets them partly from diet and largely from his genome. With the package comes an ability to be good at sport. Behaviourally, we tend to like doing what we are good at. Nature or nurture? If a kid stays slim because he exercises hard, is that genetic or cultural? Or is the question largely meaningless?

And if sport stops being fashionable among kids and his peers prefer videogames, so the same kid sits around in front of pcs, but still eats like a horse and gets obese- how much of his weight is due to genes then? It's a complex question.
 
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Yes, it does. Saying that it does not enter the equation at all

I think we have a failure to communicate here. For the second time you fail to acknowledge the sentence "or perhaps only insofar as a fraction of the appetite is concerned". Are you doing it on purpose ?

is saying that it makes no difference how much is absorbed, even in severe malabsorption conditions. You claim that people with a lower absorption rate compensate by eating more, and that it therefore does not enter the equation at all, is claiming that the absorption rate can be safely ignored. I don't think there is any evidence that are able to compensate a lower absorption rate in this way.

1. You said I ignored the absorption rate's contribution to appetite, which I clearly didn't. However, I still maintain that its contribution is minimal. Yes, for Ed's sake, you can completely leave it out of the equation as far as any practical diet is concerned.

2. You mentioned malabsorption, when I clearly said I don't talk about such conditions.

3. If (and that's a completely hypothetical "if") absorption rates were significantly different, then yes, I claim those people with lower absorption rates would compensate by eating more. It's pretty simple: They would be needing more energy.

I can't find any large measurements of individual differences of nutrient absorption rates, but it would be weird if they don't exist; all other phenotypical properties show significant variation.

However, here is a study about differences between enthnicities and possible influence of light levels in carbohydrate digestion.
here is a study that indicates that it changes with age.

Not only you won't be finding any meaningful measurements of the kind, but even if you did this wouldn't mean much. Because it would still be only relevant to the very small fraction of appetite that is relative to the volume of the food. We've had a similar discussion in the past with Blutoski, during which he suggested the book "Volumetrics" by Barbara Rolls, based on that very idea. I got and read the book and was rather underwelmed. I may offer some critique on the studies she cites vs the conclusions she draws.

Besides, it doesn't take a genious to realize that increased food volume hasn't worked very well for dieters so far. And it's not like it's a new idea either.

BTW, there's one more inacurracy which I haven't brought forward so far because the whole point is rather insignificant. But in any case, absorption is primarily a function of the gut, while appetite control via food volume is focused on the stomach.

It is also well known that how much is absorbed also depends on what you eat. Some substances increase or inhibit the absorption of other substances.

Not in any way that would be useful to a dieter. Unfortunately, the most valid way to reduce the absorption rate of macronutriets is to overeat in a small period of time, which defeats the purpose.

How much nutrients are available to the body also depends on the intestinal flora. Here is some evidence from animal studies that suggests that your weight is partly dependent on which bacteria are living inside you, because they influence how much nutrients are available to absorb.

You are attaching too much importance to factors that may be responsible for a a very small percentage of the total dietary deviations in one person's diet. Even in the last study you cited the researcher admits that "The amount of calories you consume by eating, and the amount of calories you expend by exercising are key determinants of your tendency to be obese or lean".

That's not quite true. Obesity surgery still has a fairly high failure rate because people can eat more. It just makes it really uncomfortable to eat more in one go, but unfortunately that does not stop all people.

On the contrary, this is exactly why what I said is VERY true. Stomach stapling makes people sick when they overeat, and this is why they end up taking less calories. The fact that they can gradually re-adjust to increased intake is totally different.

"They CAN'T eat more, that's why they don't." is misrepresenting how it works.

Boy, I don't know what to say. You've completely twisted the meaning of my sentence. "They CAN'T" was meant to have the same meaning as your (revised) statement "It just makes it really uncomfortable ". I already said "The main way this works is by making people feeling ill when they eat more". It's not "CAN'T" like "it's physically impossible". As opposed to what you previously said "That doesn't necessarily cause people to feel hungry and eat more."

If filling the stomach was adequate in reducing appetite, then nothing would be much easier. People have been unsuccesfully trying such methods for ages. Fiber that absorbs water, salads, water, etc. We've already tried this.

Obviously. It also suggests that there is more to the control of appetite than how much nutrients are absorbed, which is why you can't say that the absorption rate "doesn't enter the equation at all".

Not in any worthwhile degree, no matter what you say.

If you still have a point to make, please make it consice: Are you saying that different absorption rates are an important factor in determining whether one will develop obesity ? Yes or No ? Because I have the feeling that you are trying to find something to disagree with me. I have never questioned that appetite varies greatly between people. Hell, even my own appetite would only be satisfied at about 800-100 kcals above my maintenance level. But food volume and absorption rates are only very minor contributors to this, if at all. Do you disagree with my basic position that there's nothing in a healthy person's metabolism preventing him/her from losing fat (even hypothyroidism is responsible for only a 5-10% reduction in basal metabolism) ? Do you know that the number 1 reason diets fail is underestimating of ingested calories ? Because it seems to me a little strange that "absorption rates" is all you have to comment on, out of everything that has been said here.
 
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This is quite interesting. Leptin is part of a negative feedback system (a.k.a homeostasis). I.e. whatever weight you are your body tries to maintain it. I've got more details about appetite and feeding behaviour in a neuroscience book.

Thanks Ivor, that's a very interesting area indeed. If you are interested in discussing leptin, ghrelin, NPY etc and their roles in appetite and cravings regulation, start a new thread and I'll chime in. I won't be participating in this one anymore, it's made me kinda sick :D
 
.....loads of good sensible stuff......
To which I'd like to add...

Parents no longer being comfortable to let their kids out of their sight

Parents providing poor role models in terms of sporting endeavour. Not enough of my friends actively encourage their kids to take part in sports

Increased emphasis on academic attainment in schools leading to fewer opportunities to be introduced to new sports and less time for teachers to be involved with out of school activities


and of course Maggie Thatcher who personally sold off all the school playing fields
 
I think we have a failure to communicate here.
Could be.

For the second time you fail to acknowledge the sentence "or perhaps only insofar as a fraction of the appetite is concerned". Are you doing it on purpose ?
Yes. I am not talking about appetite.

1. You said I ignored the absorption rate's contribution to appetite
No, I said you ignored the absortion rate's contribution to how much nutrients are absorbed, and therefore how much can be stored as fat.

2. You mentioned malabsorption, when I clearly said I don't talk about such conditions.
If you say that "absorption rate doesn't enter the equation at all" you can't just turn around and claim that in cases of severe malabsorption it does "enter the equation". If it is relevant for people with severe malabsorption conditions, then it is also relevant to minor differences in absorption rate. Just not as much.

It's pretty simple: They would be needing more energy.
Eating more is not the only way to compensate, and I don't think it is the most likely. A person who gets less energy from food may also store less fat, and exercise less. I think it is more likely that a person with a less than average absorption rate stays skinnier than average.

Because it would still be only relevant to the very small fraction of appetite that is relative to the volume of the food.
How large is that fraction? I'd say it is fairly substantial.

You are attaching too much importance to factors that may be responsible for a a very small percentage of the total dietary deviations in one person's diet.
I'm talking about how one person compares to another person. There may be significant differences between people.

Even in the last study you cited the researcher admits that "The amount of calories you consume by eating, and the amount of calories you expend by exercising are key determinants of your tendency to be obese or lean".
Those bacteria obviously can only make calories available that exist in one's food. That does not make the amount of calories that the bacteria make available insignificant. It means that some people will absorb more calories from the same food than others.

It's not "CAN'T" like "it's physically impossible".
Unfortunately I am not psychic. If you say "can't" I tend to assume you mean "can't" instead of "can with some difficulty".

If filling the stomach was adequate in reducing appetite, then nothing would be much easier.
It may not be adequate, but I don't believe it is entirely ineffective either. If it was, what would be the point of switching to lower caloric food? Will people eat the same amount of calories in salad as they would in chocolat cake? Drink as much calories of light cola as they would do with sugared cola?

Are you saying that different absorption rates are an important factor in determining whether one will develop obesity ? Yes or No ?
I'm not ruling it out. How important a factor it is, I don't know. I do know that someone who has a higher than average absorption rate will have a more difficult time avoiding obesity than someone with a lower than average absorption rate, just because with a higher absorption rate more nutrients become available to the body than with a lower absorption rate, assuming both eat the same amount of the same thing.

Do you disagree with my basic position that there's nothing in a healthy person's metabolism preventing him/her from losing fat
Depends on how you define "healthy". I understand that the scientific consensus is that the body tends to resist losing fat.

Do you know that the number 1 reason diets fail is underestimating of ingested calories ?
Is it? I would have guesses that a more common reason diets fail is that people quit them.

Because it seems to me a little strange that "absorption rates" is all you have to comment on, out of everything that has been said here.
I feel no reason to challenge you on things of which I do not think you are wrong.
 
Russian General: We feed our soldiers 2000 calories per day!
British General: Really? Our chaps average 2500 calories , plus tea.
American General: Goddamn! Our guys eat 4000 calories every day!
Russian General: This is lie! Nobody can eat so many potatoes!
 
Man, what a thread and to think I didn't even known that fat Gene had gone missing...
 
To which I'd like to add...

Parents no longer being comfortable to let their kids out of their sight

I'm glad that not everyone missed this bleeding obvious facet in the question.

I certainly don't let my kids walk or bike to school, whereas I did either for most of the time I was at school. Traffic is far, far heavier than it was 40 years ago and like most parents, my kids get a ride to school.


Parents providing poor role models in terms of sporting endeavour. Not enough of my friends actively encourage their kids to take part in sports

Increased emphasis on academic attainment in schools leading to fewer opportunities to be introduced to new sports and less time for teachers to be involved with out of school activities


and of course Maggie Thatcher who personally sold off all the school playing fields

Fortunately, they aren't such huge problems here, kids' sport participation is very high.
 
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To which I'd like to add...

Parents no longer being comfortable to let their kids out of their sight

It's amazing these days that in neighborhoods that you know are full of kids, you never see them. When I was a kid we pretty much only came inside to eat or sleep. Irrational fear from parents (probably caused by sensational news coverage of child abductions, etc.) is surely one major cause, while improvements in indoor entertainment (cable TV, video games) is another.
 
I hope the irony of this is not lost on you.

No kidding. The last neighborhood I lived in had a single entry point (so no through traffic) and about 200 homes, yet there was constant traffic. A lot of those people made trips every day to drop their kids off at school, to pick up their kids up from school, to drop their kids off at soccer practice, to pick their kids up from soccer practice, etc. and with a complete lack of car pooling even though all of their kids were going to the same places.
 
I bump this thread because of the discussion I had with El Greco about the relevance of differences in absorption rates. That issue gets a surprising twist because of recent research: it apperently turns out that the intestines has taste buds, and has a bit of a sweet tooth. If it detects sweet tasting things, it increases the absorption of sugars.

It even works with artificial sweeteners; they can't get absorped themselves, but they do cause an increase in the absorption of the sugars you do ingest.
 
This is why science reporting should be left to people who actually understand the science. I have read the paper they are referring to (or something very similar to it). It is not "a fat gene", and calling it such is a huge leap. Like all complex disorders, this gene is associated with an increased risk of obesity. An association which, I'll admit, is statistically significant, but geneticists will tell you that it's all very well and good to have an association, no matter how strong, but without an understanding of the gene and how it affects the disorder, it doesn't help much.
 
Scientists have claimed to have found all sorts of genes. They've even found homosexuality genes! GAY GENES, FOR CHRISSAKE! Ever heard of evolution and selective pressure?

The idea being, that once provided with the patentable technology to fix the genes, they will offer that.

The way these supposed genes are found is that the genetic makeup of some people is tested on some more or less random candiate genes, and then the one with the highest correlation to the actual condition is pronounced the "cause".

Post hoc ergo propter hoc.

I wouldn't believe a single one of those "ITS THE GENES" claims. Yes, some conditions are genetic disorders. But if you claim stuff like obesity or homosexuality to be caused by genes, that's *********.
 
Scientists have claimed to have found all sorts of genes. They've even found homosexuality genes! GAY GENES, FOR CHRISSAKE! Ever heard of evolution and selective pressure?

Um, no. I think you'll find that the actual scientists make very specific claims.

ETA: Oh, and you are aware that humans are not the only animals which exhibit homosexual behaviour, right?

The idea being, that once provided with the patentable technology to fix the genes, they will offer that.

The way these supposed genes are found is that the genetic makeup of some people is tested on some more or less random candiate genes, and then the one with the highest correlation to the actual condition is pronounced the "cause".

Post hoc ergo propter hoc.

It is never pronounced the cause by the actual scientists. The only claim that can be made is that there is a correlation. Further investigation of a gene may show a mechanical causative effect, however. The methods by which these correlation studies are done is completely sound. The claims made by the media, and/or those who do not fully understand the statistical tests and what they mean, are what add additional claims to these studies which they never intended.

I wouldn't believe a single one of those "ITS THE GENES" claims. Yes, some conditions are genetic disorders. But if you claim stuff like obesity or homosexuality to be caused by genes, that's *********.

As I said earlier, since I have read this actual study, I can say that they do not claim that this gene causes obesity. They claim (and rightly so) that this gene shows a highly statistically significant correlation between having this gene and having obesity. This suggests that it is a possible risk gene, but doesn't come close to claiming that it causes obesity.
 
Hello
I was following this thread. So I think this is a good place to ask some questions.

I need to reduce 25 lb of mostly abdominal fat. 4 years ago I was very good working out with weights and table tennis cardio, but due to car accident I quit my routines and said good bye to my muscles.

During those years I tried several times to became active again but after 3-4 days I left the routines, since my motivation and stamina were very low. Just reciently I have found the motivation to do 1 hour of cardio and very low weights evry other day.

During those years also I haven't eat that much. I wasn't in a diet at all, but is not that I was eating junk food or too much sugar. But I haven't done any workout and gained all that weight in 1 year.

The compromise I have encountered acceptable for now is as follows:

- 1 hour of low intensity cardio every day.
- 20 mins of weights (low) every other day.
- Normal food (not diet but normal size portions, 3 times a day) from monday to friday, no chocolates, pizzas, sodas and so on.
- Saturday and Sunday free days, pizza, fried chicken, chocolates and sodas allowed but not in excess.

What do you think of this? will I be able to loss the 25 lb in 1 year? What could I do to gain the motivation I had those years I was excercising 2 hours a day and feeling very good with this ( I even looked forward to get home and work out)? Now I'm able to do some workout but not at even 1/3 of the intensity I used to do. And there is no way I can start a diet now.

Any takers?
 
Any takers?

Unless there is some underlying physical condition, it is likely that the way you gained that weight is by consuming more calories than you burned on a consistent basis. You need to turn that around and start burning more calories than you consume. This can be done through a combination of caloric reduction and an increase in the total amount of exercise.

You'll want to start keeping track of how many calories you consume daily because we often under-estimate our total caloric intake. Also, you may not need to necessarily increase the intensity of your workouts as long as you're getting some form of exercise. There are some formulas that estimate how many calories you burn in a day based on your height, weight and age in years, one of which can be found here.

So once you figure that out, and find out how many calories you're taking in daily, you'll be able to determine how much of a caloric reduction you need to lose weight. Mind you, you may have to play with the numbers as the BMR is just an estimate and is not accurate for everyone.
 
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So it will be correct to say that, to lose weight you should do caloric reduction and the amount of exercise plays a very small role?
 
So it will be correct to say that, to lose weight you should do caloric reduction and the amount of exercise plays a very small role?

No! Exercising uses up calories to create heat, kinetic motion, and build muscles. Larger muscles use more calories than smaller muscles, even when they're not being exercised. Excercise is a very important part of weight loss.

For instance: this website will show you the number of calories that you need to maintain your current weight (although I can't vouch for its accuracy):
http://www.calorie-count.com/calories/calories-burned.php

One pound of fat is equivalent to 3500 calories. You should never try to lose more than a pound of fat in a week, so multiply your daily calories (at your current weight and intended activity level) by 7 and subtract 3500 calories for your weekly minimum.



This is an interesting blog by an RN who feels that our culture of obesity bigotry and panic is doing more harm than the obesity itself:
http://junkfoodscience.blogspot.com/
 

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