When we will fully understand how the brain works we wil be able to transfer our selves to software. And we won't mind because we will know how to experience anything, including happiness. Indestructibility will be as simple as taking a backup.
We've only been a few generations, if that, wherein people didn't "die off" because of genetic defects, low fitness, whatever you want to call it. So yes, that is slowly degrading "the average human" genetics.
But that won't have all that much effect in the paltry few generations until genetic engineering begins to fix issues.
And given the imminent (next few hundred years) of humans becoming capable of one or more of the following: complete genetic redesign, genetic improvement of intelligence, "uploading" the mind into computers (with self-improvement via speed increases and ability increases) even the scenario of the Gattaca movie is temporary.
My own secret pet belief is that we are already living in such a world, and this one is some bizarre birthing chamber to raise new people "the old fashioned" way* because, I don't know, bitter experience shows it's necessary to produce people who are responsible, or perhaps as a "vacation land" where people could go live "the old way", although why you'd want to do it, risking rape, torture, and murder, to say nothing of pain due to accidents or stress, ya got me!
* The runner up in my mind is we're some corner of a simulation where the simulators didn't realize such as we could arise, and haven't detected us yet because we're running to fast, or are too small for notice. Worst case scenario: they realize this, and shut us off, scared of getting their NIH grant cut because of letting intelligent life evolve in their simulation.