There is one reason. The danger posed to others. There's, also, the danger to yourself, to property, and a whole slew of things that we know can happen because of that lack of knowledge. These other reasons are supportable with evidence and/or logic. However, without these other reasons to draw that conclusion, the simple lack of knowledge on how to drive large vehicles means absolutely nothing at all.
We need those other reasons to know how to interpret the lack of knowledge. What evidence or logical reasons are there to interpret the lack of knowledge about the existence of God as God not wanting us to know about him as opposed to the much simpler interpretation that God just doesn't exist?