Thomas, Dunstan: my toy example was just illustrate the idea of "low probability of great harm vs chance of moderate benefit" and how the words irrational and rational shouldn't be used to describe a decision based on these probabilities. But I'll admit that Dunstan's modified version of my game 2 is a nicer example.
CaptainManacles: You seem to be thinking of the laws of large numbers (and misstating/misinterpreting it, which is common).
I think "irrational" and "rational" could still be used within this context, and in fact, we implicitly make these type decisions all the time. That's why it's interesting to me that we're not adaptively optimized to make these decisions rationally.
I probably don't have a perfect idea of the math, but I do think with the right respective risk percentages, it's irrational not to risk losing both eyes for a gain of $5. Would one submit to a one in a googleplex risk of losing one's eyes for a 50% chance at winning $5? I certainly would, and I'd play that game over and over again for the rest of my life. Even if the marginal utility of extra $5 bills was low for me, but significantly greater than zero. I think it would be irrational not to.
We already play these games all the time. Do you leave your house to go to work or do errands? By leaving your house, your risk of losing both of your eyes probably increases slightly. But the moderate rewards you get for doing whatever day of work or errands makes it more than worth it for you.
But I believe I've read that when risks for great loss are somewhat greater than microscopic (and salient to the assessor, such as death in a plane crash is for many folks) our species shows a marked tendency for irrational decision making.