I'm not particularly worried about talking trans rights
activists out of their version of the progressive worldview, because activists are either paid to take a certain view or else highly-motivated volunteers who've passed a number of ideological purity tests. I am much more concerned with persuading regular people who've been taken in by the activist memes but haven't really thought hard about these specific issues. For that latter group, I think
@p0lka's suggested approach of clarifying the key terms might actually go quite a long way.