I think some people are attracted to this topic because they think it presents an opportunity to appear right (on the side of the marginalized against the evil bigots) without needing to have any idea what they are talking about. I guess that miscarriages of justice is similar. Some people like the idea of starting from the point of being obviously correct because they are siding with the findings of a court. In both cases they lapse back into appeals to authority/credibility and attacking people and sources rather than arguments. All of this reduces the need to do any actual thinking or critical evaluation of evidence.
You have absolutely nailed it, and I think this is true in a much wider sense also. I noticed some time ago that for many self-identified "sceptics" this is actually how they operate. Pick the side that is obviously correct, and run with it. Most of the time that actually works. Homoeopathy is bunk. Contrails are just water condensation. Man really did walk on the moon. Vaccines work. A bunch of Saudis flew planes into buildings on 9/11. Bigfoot is delusional. You're definitely on the right side of the odds arguing from these perspectives. You can appear very clever, and "sceptical", and even convince yourself that you're clever.
Even there, I've noticed a distressing lack of nuance in some quarters. For example, while vaccines work and are of immense benefit to mankind, there are side-effects and adverse reactions sometimes. But mention these, and certain pro-vaccine advocates will jump down your throat as if you were a full-blown antivaxxer. It's not about evidence, and weighing evidence, it's about defending the chosen side.
However, there are situations where this breaks down completely. Miscarriages of justice are the obvious case, and in particular the Amanda Knox situation. Court verdicts are not invariably correct, as a long string of proven miscarriages of justice demonstrates. Simply jumping into the argument asserting that a convicted person is without doubt an evil murderer is not a safe bet. And yes, people who are genuinely interested in this issue usually choose to fight the cases where they think the verdict is incorrect. There's seldom much interest in defending an obviously guilty person, so then the accusation gets thrown around, "you think every murderer is a poor innocent soul!" No, we just tend not to bother about the obviously guilty (though I was interested in the David Gilroy one, despite reaching the conclusion that yes, he's as guilty as hell).
The Amanda Knox thread is the prime example of one where the initial forum "received wisdom" was that she was guilty, and those arguing for innocence were crazy woo-woos. Finding it hard to sustain this position, many "sceptics" labelled the thread "That Thread", announced that it was "a cess-pit" and stopped participating. While continuing to declare Knox an evil monster in other threads, where the pro-Knox posters, who actually knew the arguments, couldn't reply because any such attempt was piled on with reports of "off topic" and exhortations to take your conspiracy theories where they belong.
The Knox and Lockerbie threads were actually what led to the creation of the Trials and Errors subforum, because of the constant allegations that anyone arguing that a court verdict was incorrect was being labelled a conspiracy theorist and calls for the threads to be moved out of Social Issues and Current Events to the Conspiracy Theories subforum. As Knox and Sollecito were acquitted on appeal the posters who had initially argued that they were clearly guilty simply quit the field. The thread is still regarded as a cess-pit even though it has been amply vindicated.
This thread has turned into the same phenomenon. It's "That Thread", a cess-pit where the high-minded defenders of all things trans no longer go. Any mention of the trans issue elsewhere gets jumped on with "there's a thread for that, take your bigoted ass where it belongs", and so the arguments being advanced here are never seen by most of the members. Then someone decides they'll do a bit of virtue-signalling and comes in here with the usual "be kind", "born in the wrong body", "transwomen are no threat to cis women", "they only want to pee in peace" drivel. And then acts all surprised when they get their arse handed to them on a platter.
I long ago decided that "scepticism" is just picking what seems to be the obviously rational position and defending it unthinkingly. It doesn't take much intellect and most of the time you're right. But sometimes you're wrong, and sometimes what you thought was the obviously rational position turns out to be nothing of the sort. The tide seems to be on the turn on the trans issue, although it's going to take a long time for something so tenaciously embedded in protocols and even the law to be expunged. It's just sad that this forum isn't a place where the issues can be debated rationally, but rather the debate has been confined to this ghetto and most posters refuse to participate.