I'm talking about new species.
What alterations are you talking about?
The definition of a species is rather complex and, if I understand correctly, not one that is entirely settled.
Some would argue that mules and ligers and whatnot are not really species because they can't reproduce. Even then, these are not examples of full-on design. Design would be "gee, that tiger's nice, but it lacks wings." If you're looking for something more realistic, the day-glo animals that are being produced in Taiwan might be considered intelligent design. Hybrids and domestic animals are just animal husbandry that sometimes results in speciation.