michaelsuede
Graduate Poster
- Joined
- Mar 21, 2011
- Messages
- 1,565
What is the best study?
Please link to it….
What's the best study? Probably this one:
https://republicans-energycommerce.house.gov/wp-content/uploads/2021/10/Year-5-EHA.pdf
This is my favorite part out of it:
In Year 5, we continued with in vivo infection experiments of diverse bat SARSr-CoVs on transgenic mice expressing human ACE2. Mice were infected with 4 strains of SARSr-CoVs with different S protein, including the full-length recombinant virus of SARSr-CoV WIV1 and three chimeric viruses with the backbone of WIV1 and S proteins of SHC014, WIV16 and Rs4231, respectively. Pathogenicity of the 4 SARSr-CoVs was evaluated by recording the survival rate of challenged mice in a 2-week course. All of the 4 SARSr-CoVs caused lethal infection in hACE2 transgenic mice, but the mortality rate vary among 4 groups of infected mice (Fig. 13a). 14 days post infection, 5 out of 7 mice infected with WIV1 remained alive (71.4%), while only 2 of 8 mice infected with rWIV1-SHC014 S survived (25%).