...In what way exactly? I mean obviously you have the standard privisos of all knowledge being only what is best known at the time with the possibility that our understanding will change with new information, but you can absolutely state that one explanation is correct. To pick a random example, the panoply of life is due to the systems detailed in the theory of Evolution. It just is, that's the absolute truth of the matter.
No, it's not the truth of the matter - in 5, 50, 500 years there could be 5 competing hypothesis re the panoply of life