Leptin and its effects on metabolism

Orphia Nay

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The 1994 discovery of the hormone Leptin has led to exponential incremental scientific discoveries and now its role (in obesity in particular) is becoming more widely known.

https://www.rockefeller.edu/news/26...ive-2020-breakthrough-prize-in-life-sciences/

"Jeffrey M. Friedman, whose [1994] discovery of the hormone leptin has transformed our understanding of obesity, will be a 2020 recipient of the Breakthrough Prize in Life Sciences. He is being honored for his discovery of a new endocrine system through which adipose tissue signals the brain to regulate food intake. Friedman is the Marilyn M. Simpson Professor and head of the Laboratory of Molecular Genetics at Rockefeller, as well as a Howard Hughes Medical Institute Investigator.

"The relatively new Breakthrough Prize, with its accompanying $3 million award, is the most generous prize in the sciences, and recognizes achievements in the life sciences, fundamental physics, and mathematics. The prize was established eight years ago by several Silicon Valley tech entrepreneurs, including the founders of Google, Facebook, and 23andMe.

"Friedman’s 1994 discovery of leptin, and of its receptor in the brain encoded by the obese gene, shed new light on the pathogenesis of obesity. He and his colleagues have since shown that leptin acts on sets of neurons in brain centers that regulate food intake and energy expenditure, and has powerful effects on reproduction, metabolism, other endocrine systems, and immune function."


Jeffrey M. Friedman's latest Nature article:

https://www.nature.com/articles/s42255-019-0095-y

"Leptin and the endocrine control of energy balance." - Jeffrey M. Friedman, Nature, August 29, 2019.

(pdf download available.)

Not really a debate topic, but I wanted to share this information because I did a search and did not find any use of the word "leptin" in this forum hence no thread I could bump.

I'll add that leptin research is not limited to leptin deficiency.

There is work being done on how leptin (satiety hormone) and ghrelin (hunger hormone) levels can be altered by diet in beneficial and harmful ways.

One notable finding is that crash dieting (most dieting, thanks partly to modern media extremism!) leads to hormone imbalances and binge/regain yo-yoing.
 
35 years and we don't have leptin pills yet. Hmm.. My latest read said it ain't all that important of a hormone.
 
Correction, I searched for the discoverer, not "leptin".

There is leptin replacement therapy (injections), that's in the links. It doesn't work for many people.

Skeptical Greg, that precisionnutrition link in your linked post explains this in more layman's terms than Friedman's Nature Metabolism article. It also talks about the leptin therapy.

There's also this one from the same site that talks about fructose which Lustig's reputation is a bit obsessed with.

https://www.precisionnutrition.com/all-about-fructose

Lots of hormones seem to affect hunger. e.g. women need more energy intake during certain times in a cycle.
PMS is worse if you're not eating enough.

On MFP, with regards weight loss, there are an increasing number of critical thinkers having sustainable success losing weight with "refeeds" and "diet breaks" of 1-2 weeks every 5-8 weeks, which keeps hunger/satiety (leptin/ghrelin) hormones more balanced.

Been learning bits about evolutionary psychology.

Running and exercise help with stress and burning off our fight/flight instincts when most of us have desk or indoor jobs that can be very stressful. But too much intense exercise increases stress (adrenaline and cortisol). I've suspected for a while that the way it's difficult for men is because testosterone compels them to continually compete. It's certainly pretty bad for women comparing ourselves to others in the gene pool. I have more I could say about this all leading to injuries.

But dopamine and serotonin can also be nice happy comfortable influencers that make competitiveness less important and make us want to be happy just being with our people around our campfire safe from wild animals.

I guess these hormones can also be part of the reason people want to stick to a diet their peers prefer.
 
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Yes.. That last comment I made, was based on the link you provided up-thread.
I found it very interesting and in line with a lot of my thoughts, and other evidence I have gleaned on the subject.
 
Yes.. That last comment I made, was based on the link you provided up-thread.
I found it very interesting and in line with a lot of my thoughts, and other evidence I have gleaned on the subject.

:thumbsup: :) Sorry, which link upthread?

ETA: The link about sugar is a bit more well-rounded than the fructose one.

I found fructose combined with maltodextrin/glucose etc to be a good carb source in marathon training, due to the sugars being absorbed via different pathways.
 
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35 years and we don't have leptin pills yet. Hmm.. My latest read said it ain't all that important of a hormone.

Basically. It was a whoop de doo theory a generation ago that didn't pan out.

That doesn't stop quacks from going on about it.

James Randi referred to these as unsinkable rubber ducks.

Leptin's one of them. It's an obesity version of cold fusion.
 
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It's kind of like discovering that gasoline has significant importance in how a car functions, and then being disappointed when further research reveals that throwing gasoline at the car doesn't improve its performance.
 

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