I'm not sure exactly what "rational" means, as we're using it here. I think it would be interesting to try to formulate a careful definition.
My understanding is that "rational" is actually shorthand for a number of concepts. In general, a "rational" player is knowledgeable (she understands the rules of the "game" and the various options available to her), self-aware (she understands the payoff matrix and will act to maximize her expected payoff), mathematically capable (her calculations of "expected payoff" are correct), and, finally, risk-neutral (meaning that she's only interested in the "expected" payoff and is not concerned with risk management).
But the theory of games itself is essentially a definition of what "rational" behavior is -- really, under the standard formulation, the "rational" player is the one who does what game theory says she should do. The point is that if you do something that does not maximize your expected payoff, you are doing something wrong and "irrational." The question, of course, is what should you do to achieve that maximum?
But, in the meantime, it seems clear to me that the assumption of rationality, together with the assumption that you can't control the other person's choice, implies that, when trying to decide what choice to make, you should compare outcomes that are identical except for your choice, because your choice is all that you control.
It's actually a little simpler than that. A fundamental concept of game theory (from the original Von Neumann and Morgenstern formulation) is that of "domination." Strategy X "dominates" strategy Y (X >> Y) if and only if, for every possible situation, the payoff of strategy X is greater than or equal to the payoff for strategy Y (and they differ in at least one situation). It's an easy theorem that in such a situation, a "rational" player should never play the dominated strategy.
Notice that in this formulation, there is no real notion of "what the other player thinks," because it's not necessary. Your opponent may be rational, your opponent may not be rational -- you neither know nor care.
And, obviously, the strategy of "confess" dominates "remain silent." Q.e.d.