Rolfe
Adult human female
Well, you know, I don't know what the truth is on that. Much of the positive follow-up seems to be based on voluntary questionnaires, or looking at records of patients easily contactable because they're still in the system. I have read critiques saying that there is an element of cherry-picking, conscious or unconscious, because the unhappy patients are more likely to withdraw from engagement and so not be picked up by this sort of study.
But on the other hand I know a number of male-to-female trans-sexuals who are indeed very happy with their outcome and who wouldn't go back. One feature mentioned in the Johns Hopkins context however was very long-term follow-up, and increasing depression after several decades. Much of the modern follow-up seems to be shorter term. In particular the long-term effects of testosterone on a female body are likely to be problematic, and we all know about the reservations regarding giving progesterone to post-menopausal women, what do we know about giving it to men for decades?
I don't know one way or the other and I'm not sure there are definitive studies. The sort of study that demonstrated the increase in breast cancer in women receiving HRT simply doesn't seem to be being done on sex reassignment patients taking similar hormones, even though the fact that in that case the hormones ae being administered to bodies not actually intended to cope with that endocrine environment might be expected to increase the risk of adverse events.
It seems a bit ironic that women often can't get HRT for a bad menopause now because prescribers are concerned about what is a relatively small increase in risk, even though it's statistically significant, but off-label use on the opposite sex is happening relatively freely. It's also a concern thay very young people are starting on cross-sex hormones without much in the way of informed consent in many cases. They're expecting to stay on these hormones for the rest of their natural life, but what will this do to them? Or to some of them at least?
But on the other hand I know a number of male-to-female trans-sexuals who are indeed very happy with their outcome and who wouldn't go back. One feature mentioned in the Johns Hopkins context however was very long-term follow-up, and increasing depression after several decades. Much of the modern follow-up seems to be shorter term. In particular the long-term effects of testosterone on a female body are likely to be problematic, and we all know about the reservations regarding giving progesterone to post-menopausal women, what do we know about giving it to men for decades?
I don't know one way or the other and I'm not sure there are definitive studies. The sort of study that demonstrated the increase in breast cancer in women receiving HRT simply doesn't seem to be being done on sex reassignment patients taking similar hormones, even though the fact that in that case the hormones ae being administered to bodies not actually intended to cope with that endocrine environment might be expected to increase the risk of adverse events.
It seems a bit ironic that women often can't get HRT for a bad menopause now because prescribers are concerned about what is a relatively small increase in risk, even though it's statistically significant, but off-label use on the opposite sex is happening relatively freely. It's also a concern thay very young people are starting on cross-sex hormones without much in the way of informed consent in many cases. They're expecting to stay on these hormones for the rest of their natural life, but what will this do to them? Or to some of them at least?
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