Maybe, but the reason why Iran has bad relations with USA is internal. Iranian political system is not built on very stable foundations, it started off as a religious nut-job state, which lasted a while, but is now wearing off. Their raison d'etre has gone the way of the Dodo, their other potential boogeyman (Saddam) assumed room temperature a decade ago and the Mules in power are out of options. They must either reform the country or ensure they are in a constant state of conflict near war, so they can explain to their population why they must be patriotic and not seek out ways to reform, or else their entire society might collapse, or something. They obviously picked the latter option because it keeps them in power.
Israel is their primary choice. It's not really out of ideology any more (though I'm sure it started off as such), but it's too small and too far to present a credible threat. USA is the next natural choice, especially since it cares about Israel. In the past few years KSA stepped up too, due to conflicts in Iraq and Yemen.