Here's the problem as I see it. Italians can pretty much do whatever mischief they want to do to other Italians. It's in the unwritten part of their Constitution. Eventually, the ECHR may right a situation, although they're swamped with applications against Italy, and some other "advancing" or "developing democracy" nations, for example, Ukraine, Russia, Turkey, and to a lesser degree, some of the smaller former Communist bloc countries.
If and when Italy requests extradition for Amanda Knox, they will need to provide the motivation report. When Department of State and Department of Justice lawyers read that report, presumably the Nencini one, they will be laughing and crying so hard that no further action will be taken.
Probably the best that people outside of Italy, and not in the ECHR bureaucracy, can do for Raffaele, if he is convicted, is to petition the Minister of Justice and the President of Italy to pardon him.