The Novelli paradox
Consider the Busco case: “According to Professor Giuseppe Novelli, ordinarius of genetics at Tor Vergata, ‘There were contaminations among items and for [=of?] the analyses on the corsage and on the bra. The chain of custody of the items did not respect national and international standards for the conservation of items.’” I find it...interesting...that Dr. Novelli acknowledges national and international standards.
A review article coauthored by Giardini, Spinella, and Novelli stated, “Thus in these conditions [less than 100 picograms of DNA] there is a greater probability of artefacts, partial profiles with fewer alleles, contamination, preferential allele amplification, the complete absence of one allele (allele drop-out) in heterozygous loci and the nonspecific generation of extra alleles (allele drop-in) [78,79]…. Very few laboratories perform low template DNA typing properly, because it requires dedicated facilities and great experience, although there are several published methods for the interpretation of such profiles [80-82].” (highlighting mine)
And yet Novelli has no criticisms for a lab that was not yet accredited to perform standard DNA profiling, let alone low template profiling.