Most of the applications to the ECHR from Italy are from Italian citizens (at least their names seem Italian - see HUDOC and look for cases against Italy); I don't believe those relatively few from non-Italians make much difference. There are so many from Italians that Amanda Knox's application will in a sense be hardly noticed.
Similarly, most cases against any of the ECHR CoE States are from their own nationals.
http://www.echr.coe.int/Documents/CP_Italy_eng.pdf
Italy
Applications pending before the
court on 04/07/2014
Total pending Applications 23347
Applications pending before a judicial
formation: 15497
Single Judge 480
Committee (3 Judges) 4406
Chamber (7 Judges) 10610
Grand Chamber (17 Judges) 1
If a judge is unaware of this case, I would wonder what planet he is on, or how much LSD he used in the 1960's.
{Emphasis added to quotes.}
Just a clarification: Both quotes have validity. Note the qualifier "in a sense" in the first quote. BTW, some of the ECHR judges are women, so "he" in the second quote should be regarded as not exclusive regarding gender.