'Silence of the Lambs' featured a transgender killer. Indeed, Hollywood films are littered throughout history with, 'dangerous faggots and crazy queers'.
There was a Frank Sinatra detective movie that features a forced confession from a "homosexual!", that is just painful to watch.
Michael Douglas and Walter Matthau chased down a machine gun spraying Bus riding gunman in San Francisco, who was also apparently driven mad by being gay.
Richard Benjamin once played a 'homosexual!", who at the very end of the movie, revealed himself to be the crazed gay killer, while wearing two sock puppets he horrifyingly stuffed into the camera lens (I could make that up?).
Sadly, it is a common motif. Using sexual orientation, race, religion, any point of departure from the social norm that can be used to accentuate "otherness", at some point turns to... murder! At least in the Hollywood of days gone by.
Times are changing, but these movies last forever.