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Pregnancy, Flu and Schizophrenia

The news article mentions women, the abstract of the actual study only mentions mice. So. maybe time for more studies.

Hmmm, I wonder if there is a possible link to other behavior patterns? Work ethic? Sexual appetites? Right/left handedness?

Would the age of the mother come into play? Older moms would have been exposed to more pathogens, so have less chance of contacting the disease.
 
It's interesting that it's not even the actual flu virus that does it. It's the mother's immune response. (probably inflammatory cytokines).
 
The news article mentions women, the abstract of the actual study only mentions mice. So. maybe time for more studies.

The association with women is based on prior studies. Here is a reference for that association. Since the studies in women are not experimental, but observational and subject to bias, it cannot be assumed that a causal link has been established. The positive result in a mouse model (if the model is valid?) is interesting, though.

Linda
 
Is it really possible to positively diagnose schizophrenia in mice?
 
Is it really possible to positively diagnose schizophrenia in mice?

When they tell you they're hearing voices and are clearly suffering from delusions of grandeur, it's pretty obvious.
 
The association with women is based on prior studies. Here is a reference for that association.
Linda

From that study's results:
" It should be noted, however, that this finding did not achieve statistical significance (P = .08) and is based on a small sample."

But it is good to know that things like this are being studied.
 
While i will admit that i haven't investigated the pregnant with flu link to autism, i have heard from a credible source(one that i trust a lot) that it is on the up and up...
 
I haven't had time to listen to this (and I'm not sure it will run on my computer), but it looks to explain how Patterson supports his use of the mouse model for human schizophrenia.

This news account had a tiny bit more info. I can't open the link of Linda's in RTF. I'd like to know if the actual research considered any viral infection or specifically influenza. Reporters never seem to properly distinguish the two.

Professor Paul Patterson from the California Institute of Technology
has told a neuroscience conference in Melbourne that it's a protein produced by pregnant women to help fight infection that leads to an increased risk of the baby becoming schizophrenic or autistic.

Fellow neuroscientists say the finding is in line with other research being carried out in the field, but stress that genetic factors also play a key role in the development of mental illnesses.

PAUL PATTERSON: It appears from our work that the body's natural mechanism for fighting a virus, which includes producing proteins in the blood, some of those proteins, one in particular called Interleukin Six, is a key for altering foetal brain development that leads to these abnormal behaviours.

PAUL PATTERSON: Well in humans it's not the majority, it's an increase of about three to seven-fold over normal.

Of course not every woman who gets a cold during pregnancy will have a schizophrenic offspring, that's because of… presumably because of the genotype, you have to have a certain set of genes to be susceptible to these environmental insults.

BARBARA MILLER (Interviewer/reporter): Professor Patterson's research has not yet been accepted for publication. But Professor Ian Hickie from the Brain and Mind Research Institute at the University of Sydney says the findings appear to be in line with other work being carried out in the field.

IAN HICKIE (Professor, University of Sydney's Brain and Mind Research Institute.): I think it adds further to the research that has been going on in looking for the specific aspects of the immune response in the mother that may be affecting the brain development in the child.

And that's one of the strong theories in schizophrenia is that there is something in the environment that alters the brain development early on in children who later go on to develop schizophrenia in later life.
 
I haven't had time to listen to this (and I'm not sure it will run on my computer), but it looks to explain how Patterson supports his use of the mouse model for human schizophrenia.

This news account had a tiny bit more info. I can't open the link of Linda's in RTF. I'd like to know if the actual research considered any viral infection or specifically influenza. Reporters never seem to properly distinguish the two.

It was specifically influenza.

Here is the abstract:

ACTIVATING THE MATERNAL IMMUNE SYSTEM CAUSES CHANGES IN THE OFFSPRING RESEMBLING THOSE IN SCHIZOPHRENIA AND AUTISM
Patterson P.H.
California Institute of Technology.
Maternal viral infection is associated with increased risk of schizophrenia and autism in the offspring. In a mouse model based on this risk factor, we found that respiratory infection with influenza virus leads to behavioral abnormalities in the adult offspring. These behaviors are consistent with abnormalities seen in schizophrenia and autism, including enhanced anxiety in the open field (OF), as well as deficits in social interaction (SI), latent inhibition (LI) and prepulse inhibition (PPI). The latter is corrected by anti-psychotic and exacerbated by psychomimetic drugs. The adult offspring display neuropathology in the cortex and hippocampus similar to that found in schizophrenia and a localized deficit in Purkinje cells that resembles that in autism. The cause of these various abnormalities is the maternal response to viral infection, as treatment of uninfected, pregnant mice with the dsRNA, poly(I:C), which evokes an anti-viral-like immune response, also induces OF, SI, PPI and LI deficits and the Purkinje cell deficit in the offspring. Exploring potential mediators of these effects revealed that injection of the cytokine IL-6 in normal pregnant mice causes PPI and LI deficits in the offspring, while co-injection of anti-IL-6 antibody with poly(I:C) in pregnant mice blocks the effects of maternal immune activation on the behavior of the offspring. Moreover, the offspring of poly(I:C) treated IL-6 knockout mice do not display behavioral abnormalities. Furthermore, maternal anti-IL-6 blocks the changes in gene expression in the brains of adult offspring that are caused by maternal poly(I:C) treatment. Therefore, IL-6 is a key mediator of the effects of the activated maternal immune response on fetal brain development. Supported by the NIMH, and the McKnight, Autism Speaks, and Cure Autism Now foundations.

Linda
 
Next question: What other 'diseases' cause the body to make IL-6?

Off to Google...

ETA: That only took the first hit. From Wiki:

" IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction[2]."

So it looks likely that the mental problems related to mitochondrial disease are only peripherally related. Bad muscles could be the cause, not mitochondrial function in nerve/brain cells.
 
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But it might be IgG, too...

http://archpsyc.ama-assn.org/cgi/content/full/61/8/774

Since influenza is believed to only rarely cross the placenta, an indirect effect on fetal brain development is the most plausible pathogenic mechanism linking it to an increased risk of schizophrenia.24 One such mechanism, previously considered, is that maternal IgG antibodies elicited by influenza traverse the placenta and cross-react with fetal brain antigens by molecular mimicry, thereby disturbing fetal brain development and increasing vulnerability to schizophrenia.
 
I know this is only anecdotal, but my grandmother had the flu and rubella when pregnant with my mother. My mother has severe paranoid-type schizophrenia, and is deaf as well.

Edited to add:
When they tell you they're hearing voices and are clearly suffering from delusions of grandeur, it's pretty obvious.

That isn't even remotely funny.
 
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They've known of the link between second trimester flu and schizophrenia for some time.

Rubella during pregnancy is known to produce a constellation of symptoms including deafness, blindness, and mental retardation to varying degrees--but I don't think it increases the risk for schizophrenia.

The autism link is provocative. The mother's immune system is implicated in a finding that later born brothers are more likely to be gay than their old male sibliings. There are noticeable brain differences in people with some types of autism and in schizophrenia, so I think they are able to identify some of these changes in mice brains as well.
 
I know this is only anecdotal, but my grandmother had the flu and rubella when pregnant with my mother. My mother has severe paranoid-type schizophrenia, and is deaf as well.

Edited to add:


That isn't even remotely funny.
I thought it was funny. I'm sure kelly meant no harm by it. But I'm sorry about your mother. That must be incredibly difficult. My situation is different but I can imagine how hard yours must be. My mother is developing Alzheimer's and it is quite depressing. I find myself grieving because I miss her company regardless that her physical presence is still here.

There was a lot of research on the Net discussing how the mouse model is correlated with human schizophrenia.

Just because Rubella hasn't been connected with schizophrenia doesn't mean the connection isn't there. The research abstract also says
The cause of these various abnormalities is the maternal response to viral infection, as treatment of uninfected, pregnant mice with the dsRNA, poly(I:C), which evokes an anti-viral-like immune response, also induces OF, SI, PPI and LI deficits and the Purkinje cell deficit in the offspring.
suggesting it is the body's response to something more general in the viral infection rather than specific damage by the influenza virus. I've recently been reading some research into the viral mechanisms of pathology and the discussion of the mechanism which rubella causes arthritis was pretty interesting. In that case the pathology was specifically being initiated by the rubella virus.

The case in the OP discusses something initiated by the body's response instead. It might be sort of a chicken and egg argument though. I'll have to re-read the viral mechanisms involved in the arthritis now to get a more clear picture in my mind.
 
With influenza, since the virus doesn't (usually) cause viremia, but rather stays in the lungs, nose, etc....it would have to be the immune response, wouldn't it?


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By the way, catfish, I am sorry if I offended you. If it makes you feel any better, I'm epileptic, and my first reading about rodents being used as models for psychological issues was when I stumbled across a paper called "Paranoia in Rats with Temporal Lobe Epilepsy"....which brought to mind some rather funny mental images at the time. Turned out to be an interesting study, though, where the researchers initially set out to see if a series of gran mal seizures cognitively impaired the rats enough to show up on maze tests, but they never found out, because the epileptic rats just started climbing the walls in an attempt to escape, not at all worried about finding the cheese.
Anyway, I do think using mice and rats for models of complex psychological disorders has a lot of room for error, but I guess its all we've got sometimes. Or is at least a start.
 
This is fascinating science. Thanks for the links, everyone, I will tag them for perusal and digestion.

Thanks all. :)

Cheers,
TGHO
 

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