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pertussis, titers, breastfeeding

Barbrae

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Jun 26, 2004
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Does anyone know if an adult can get titers done for pertussis? I mean, I know they can - but if requested would a doctor just do it?

If titers showed the mother to be protected and she breastfed soley for the first 6 months (the time an infant is unprotected because they have yet to recieve full vaccination) How much protection would this offer?

Also, Rolfe had mentioned a long time ago somthing to the effect that breastfeeding and vaccination don't mix. That the breatsfeeding can interfere with the vaccine - Rolfe, did I get this wrong? Am I remembering this incorrectly. If it is the case does anyone have any infor on this?

Thanks
 
Barbrae said:
Does anyone know if an adult can get titers done for pertussis? I mean, I know they can - but if requested would a doctor just do it?

If titers showed the mother to be protected and she breastfed soley for the first 6 months (the time an infant is unprotected because they have yet to recieve full vaccination) How much protection would this offer?

Also, Rolfe had mentioned a long time ago somthing to the effect that breastfeeding and vaccination don't mix. That the breatsfeeding can interfere with the vaccine - Rolfe, did I get this wrong? Am I remembering this incorrectly. If it is the case does anyone have any infor on this?

Thanks

Why do you need to know, Barb? Seriously, don't you just advocate against vaccination regardless? I don't think our mission here is to educate you on things you should already know as a purported health practitioner.

-TT
 
Barbrae said:
Does anyone know if an adult can get titers done for pertussis? I mean, I know they can - but if requested would a doctor just do it?

If titers showed the mother to be protected and she breastfed soley for the first 6 months (the time an infant is unprotected because they have yet to recieve full vaccination) How much protection would this offer?

Yes this would provide some protection. Colustrum has very high titres of antibody

Also, Rolfe had mentioned a long time ago somthing to the effect that breastfeeding and vaccination don't mix. That the breatsfeeding can interfere with the vaccine - Rolfe, did I get this wrong? Am I remembering this incorrectly. If it is the case does anyone have any infor on this?

Thanks

This only applies to live vaccines (except polio) such as the MMR which establish a systemic infection and where the breastmilk antibodies can neutralise the vaccines in the virus. But this is why live vaccines are given after 12 months when breastmilk antibodies have declined.
 
Barbrae said:
...If titers showed the mother to be protected and she breastfed soley for the first 6 months (the time an infant is unprotected because they have yet to recieve full vaccination) How much protection would this offer?...

Not much... because if it did provide much protection then babies would not be in such high risk:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=14615725 ..
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15545851 ...
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15231967

and hospitals would not freak so much when it is found out that someone exposed infants to pertussis:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15566032

Anecdote time.... it didn't help this family:
http://www.metrokc.gov/HEALTH/immunization/newsstories.htm#pertussis

Personal Anecdote time:

I had chicken pox as a kid, which means that I do have the bits of the virus running through my body. Right now I have active antibodies against the virus preventing a shingles outbreak... but that can change in the future.

A year before the chicken pox vaccine became available all my kids got it. Even my 6 month old daughter who was still being breastfed... almost exclusively.

Trust me... it is miserable to have a 6 month old baby with chicken pox.

It is from this experience that I think that relying on breastfeeding for immunization is foolish.
 
Re: Re: pertussis, titers, breastfeeding

Hydrogen Cyanide said:

Personal Anecdote time:

I had chicken pox as a kid, which means that I do have the bits of the virus running through my body. Right now I have active antibodies against the virus preventing a shingles outbreak... but that can change in the future.

A year before the chicken pox vaccine became available all my kids got it. Even my 6 month old daughter who was still being breastfed... almost exclusively.

Trust me... it is miserable to have a 6 month old baby with chicken pox.

It is from this experience that I think that relying on breastfeeding for immunization is foolish.

Hey, I have almost the exact same anecdote. Except my son was 7 months old, almost exclusively breastfed and he still got chickenpox. And yes, it was miserable. And then shortly after the chickenpox, he got Juvenile Rhuematoid Arthritis.
 
I believe this powerpoint presentation answers a lot of your questions, B. Sorry it is a long download but the HTML version didn't have the graphs which were 1/2 the data. The link has some very good data I think if you look at carefully might make you consider the benefits of vaccine for pertussis in infants.

Pertussis

Maternal antibody is not enough to afford protection.

There is a lot of epidemiology discussed including some you brought up on the other thread. In this case the high likelihood of having pertussis was in patients with cough > 2 weeks so keep that in mind.
 
Re: Re: pertussis, titers, breastfeeding

ThirdTwin said:
Why do you need to know, Barb? Seriously, don't you just advocate against vaccination regardless? I don't think our mission here is to educate you on things you should already know as a purported health practitioner.

-TT

Wow - you are a complete jerk. Why do I need to know? Because I am pregnant with my third child right now and when the child is born my oldest will be at the stage where her protection is waning. As studies show over 50% of cases are transmitted by older, no longer protected siblings (thanks skepticgirl for that info on your link btw). No, I don't advocate against vaccination smartass, both my kids are vaccinated, I advocate informed, unbiased choice however and would like to think anyone with half a brain would do the same.

No it isn't your mission, but wouldn't it be nice to share information if you have it. Regarding your "purported health practitioner" comment, apparently my kids pediatricians don't know the answer either as I was assured by one that my youngest could not get Chicken pox even when she was exposed at 3 months because I was exclusively nursing. Unless the other posters here were lying about their experiences, which I doubt.

I have no problem admitting when I don't know somehting and asking others who may be more knowlegdable than me, it's called learning.
 
Capsid -

thanks for the reply. DO any studies show just how much protection would be afforded by breastfeeding? You said colostrunm is high in antibodies but does that protection continue after the colostrum is gone?
 
Re: Re: pertussis, titers, breastfeeding

Hydrogen Cyanide said:
Not much... because if it did provide much protection then babies would not be in such high risk:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=14615725 ..
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15545851 ...
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15231967

and hospitals would not freak so much when it is found out that someone exposed infants to pertussis:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15566032

Anecdote time.... it didn't help this family:
http://www.metrokc.gov/HEALTH/immunization/newsstories.htm#pertussis

Personal Anecdote time:

I had chicken pox as a kid, which means that I do have the bits of the virus running through my body. Right now I have active antibodies against the virus preventing a shingles outbreak... but that can change in the future.

A year before the chicken pox vaccine became available all my kids got it. Even my 6 month old daughter who was still being breastfed... almost exclusively.

Trust me... it is miserable to have a 6 month old baby with chicken pox.

It is from this experience that I think that relying on breastfeeding for immunization is foolish.


HC - none of the links say anything about the mothers breastfeeding at all.
 
skeptigirl said:
I believe this powerpoint presentation answers a lot of your questions, B. Sorry it is a long download but the HTML version didn't have the graphs which were 1/2 the data. The link has some very good data I think if you look at carefully might make you consider the benefits of vaccine for pertussis in infants.

Pertussis

Maternal antibody is not enough to afford protection.

There is a lot of epidemiology discussed including some you brought up on the other thread. In this case the high likelihood of having pertussis was in patients with cough > 2 weeks so keep that in mind.


Thanks fopr the link. I have started looking it over - it is long. I am not debating the benefits. What I am wondering is if a mother breastfeeds (and has proven antibodies for pertussis) would the child be protected during the time it is not fully vaccinted - if the regular vaccination schedule was followed.
 
Capsid - you said "This only applies to live vaccines (except polio) such as the MMR which establish a systemic infection and where the breastmilk antibodies can neutralise the vaccines in the virus. But this is why live vaccines are given after 12 months when breastmilk antibodies have declined."

Interesting, so breastmilk has no adverse effect on other vaccines? So, what you are saying is that if an infant were given a live vaccine and the mom was nursing the antibodies in the breastmilk would "fight" the infectious agent in the disease and therefore the infant would not develop it's own antibodies towards that disease and when mom stopped nursing it would be defenseless so to speak? Do I understand you right?
 
Re: Re: Re: pertussis, titers, breastfeeding

Barbrae said:
HC - none of the links say anything about the mothers breastfeeding at all.

I tried to find them... and there is some ithe breastfeeding bit is in the full aritcle. But the main thing is that pertussis is very dangerous to infants --- and in none of them do they mention "But the infants who were breastfed are more protected". If that were the case... it would be stated as such.

But breastfeeding does not impart magic immunity to ALL diseases.

Editted to add: If you look at the graphs in the link provided by skeptigirl you will notice MOST of the cases of reported pertussis were for babies, and the ones of those most likely to die were under 6 months. That is the population that would most likely be breastfed.

Again... if lack of breastfeeding was a factor, it would have been noted.

If you have documentation of HOW much immunity is imparted by breastfeeding, please share it.
 
Okay. We have someone claiming somebody else told them that vaccination interferes with the non-protection that breastfeeding offers??
Rolfe??? Care to explain what might be a mistaken perception of what you might have posted at one time?

Maternal antibody is not enough to afford protection.

From the link provided:

90% of the index cases were < 4 years and all had classic pertussis...

I'm reading that to mean that 90% of the cases were under age 4.

So how could
over 50% of cases are transmitted by older, no longer protected siblings
????

I looked for this stat, and didn't find it. Please quote it with the page number from the study
 
Re: Re: Re: pertussis, titers, breastfeeding

Barbrae said:
Wow - you are a complete jerk.

And, you are a complete hypocrite.

Pick your path, Barb. Your fake, woo-woo world of make believe medicine, or the legitimate, evidence-based world of real medicine.

Funny how the rats jump from the burning ship, especially when their own progeny are involved, isn't it?

-TT
 
Re: Re: Re: Re: pertussis, titers, breastfeeding

ThirdTwin said:
And, you are a complete hypocrite.

Pick your path, Barb. Your fake, woo-woo world of make believe medicine, or the legitimate, evidence-based world of real medicine.

Funny how the rats jump from the burning ship, especially when their own progeny are involved, isn't it?

I'm not familiar with Barbae's posting history or stated opinions. However in this particular thread she has behaved exactly as we would wish people to do: she has asked the right questions, read the links people have pointed her to, and asked the right questions again. She has also been polite.

Whereas, in this particular thread, you have been fairly rude.

Could I ask you to be nice, and save personal criticism of Barbrae for threads where she deserves it (if any)?
 
I'm suspicious of barb's tactics here...misquoting Rolfe and the study.

Unless I see proof otherwise, of course.
 
Barbrae said:
Capsid - you said "This only applies to live vaccines (except polio) such as the MMR which establish a systemic infection and where the breastmilk antibodies can neutralise the vaccines in the virus. But this is why live vaccines are given after 12 months when breastmilk antibodies have declined."

Interesting, so breastmilk has no adverse effect on other vaccines? So, what you are saying is that if an infant were given a live vaccine and the mom was nursing the antibodies in the breastmilk would "fight" the infectious agent in the disease and therefore the infant would not develop it's own antibodies towards that disease and when mom stopped nursing it would be defenseless so to speak? Do I understand you right?
Yes and no so to speak.

First let me say the Pertussis presentation shows the highest risk for infants getting Pertussis infection is in the first few months of life. Clearly maternal antibody is not preventing disease. And if breast feeding were delivering protective antibody you would expect to see an increase in pertussis cases as children were weaned. Instead what you see is a decrease in cases that closely matches vaccine schedules, not increasing cases with dwindling maternal antibody.

I see from your posts that you are coming up with some personal hypotheses about how vaccines, mom and baby factors interact. While there is nothing wrong with that, those hypotheses have already been explored. It isn't that you are thinking of natural ways to deal with disease and the rest of us just automatically favor drugs.

There are many references that have been presented here that for some reason are not sufficient enough to convince people why we vaccinate. I suspect, some of them, like yourself, may be interpreting the information they are reading without a full understanding of what the data really says. Clearly you have a very good understanding, and you are reading a lot of material, but you have drawn some incorrect conclusions by applying what you are reading in a broader way than the research actually supports.

I suggest you start with a different approach to the information. The outcome you want to see in any research is, "Was disease prevented?" The outcome is not who gets what from whom, how many germs did you kill, what is the antibody level etc. Those are intermediary steps but one cannot guarantee they lead to less disease.

It isn't hard to look at the data showing what disease risks you can prevent with vaccinations. The risks posed by the vaccines is a tiny fraction of the risk posed by the diseases they prevent.

Back to the nursing and it's affect on live vaccines, and Capsid may answer as well but I think it never hurts to hear the information in different ways.

Maternal antibodies have some protective ability, that's obvious. But you cannot say, breastfeeding or not, which kids are protected, from which diseases, and until what age. If the antibodies were sufficient, then no breastfeeding kids would ever get infections the mom was immune to. But, that isn't the case.

When the decision was made to use 15 months, (and at least 12 months), to give MMRs it was based on a higher failure rate showing up in kids vaccinated before 12 months. The reason may have included many variables with residual maternal antibody being one likely possibility. During a measles outbreak, we sometimes recommend giving MMR vaccine at 6 months and revaccinating with 2 more doses on the regular schedule later. Because breastfeeding does not confer sufficient immunity to be reliable.

So again, you have to be careful drawing conclusions with some of this information.


I know it's been said before but if you want the best papers to read about vaccines, on the CDC web site, for every vaccine we use today, there is an extremely thorough evaluation in a document called the ACIP, (Advisory Committee for Immunization Practices), guideline. The vaccine risks, benefits and rationale for the recommendations are discussed in detail and completely referenced with the supporting data cited, (usually several hundred documents are cited). The ACIP Guidelines are also updated whenever new data or new issues are found.

There are also documents that address the questions such as why Hep B vaccine is still recommended at birth. I notice you mentioned you delayed your middle child's Hep B vaccine. These decisions are not made lightly. They are not made by vaccine companies. The CDC is probably one of the few government agencies that does not have a revolving door for corporate jobs.
 
Re: Re: Re: Re: Re: pertussis, titers, breastfeeding

Kevin_Lowe said:
I'm not familiar with Barbae's posting history or stated opinions. However in this particular thread she has behaved exactly as we would wish people to do: she has asked the right questions, read the links people have pointed her to, and asked the right questions again. She has also been polite.

Whereas, in this particular thread, you have been fairly rude.

Could I ask you to be nice, and save personal criticism of Barbrae for threads where she deserves it (if any)?
It's easy to get into a personal battle but it only wastes time as no one listens to the other under the circumstances.

One thing I find in posting answers to Barb's questions is she has revealed at least a couple reasons misconceptions may be believed about vaccines. Whether I or anyone here gives her information that changes her thinking isn't the only reason to have this discussion. Asking the questions and giving the viewpoint of persons not quite convinced about vaccinations is the best way to learn where the mis-communication or mis-thinking is going on. Or, sometimes, it is me that has missed something, so I don't mean it is only a one way street.

And I don't mean, Barb, that you are way out in left field because I don't get that impression at all.

Additional note to my above post: After re-reading your question about protecting an infant from pertussis, if you are asking can any baby be 100% protected, you can come close with some but not all kids will be protected and there isn't a readily available test to tell you which kids are immune..

You have to remember there is more to preventing disease than just immunity issues. We also prevent as much disease as possible with the 'herd immunity' mentioned. And then there are the personal practices such as hand washing and not exposing newborns and young babies to people with symptoms or to crowds.
 
Barbrae said:
Capsid -

thanks for the reply. DO any studies show just how much protection would be afforded by breastfeeding? You said colostrunm is high in antibodies but does that protection continue after the colostrum is gone?

No. It's not complete protection, don't rely soley on it. I think the information is based on the known half life of the antibodies and other studies which have shown poor MMR vaccine take in children under 6 months of age and this was directly correlated to the maternal antibody titres neutralising the vaccine virus.

This is from Topley & Wilson's Microbiology and Microbial Infections, Ninth Edition

"Finally, in infections where transmission is common among young children, the influence of maternal antibody is a highly significant factor. For example, the incidence of meningococcal disease in infants bears an inverse relationship to the decline in maternal antibody."

Remember also that there is antibody transfer via the placenta.
 
Barbrae said:
Capsid - you said "This only applies to live vaccines (except polio) such as the MMR which establish a systemic infection and where the breastmilk antibodies can neutralise the vaccines in the virus. But this is why live vaccines are given after 12 months when breastmilk antibodies have declined."

Interesting, so breastmilk has no adverse effect on other vaccines? So, what you are saying is that if an infant were given a live vaccine and the mom was nursing the antibodies in the breastmilk would "fight" the infectious agent in the disease and therefore the infant would not develop it's own antibodies towards that disease and when mom stopped nursing it would be defenseless so to speak? Do I understand you right?

Yes that is the jist of it.

It's not just breastmilk, it's maternal antibodies which include those transferred across the placenta.

This only works on live vaccines and only where the virus can be neutralised by the antibody in the blood; killed vaccines do not enter the blood at all.
 

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