How can our brain make pain when we get a sprain?

Iamme

Philosopher
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Aug 5, 2003
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I felt some pains last night as I watched tv last night, while being under the weather with some sort of virus. I am talking an excruciating intermittant pain in my finger. Sort of gout-like.

This got me thinking; how on earth is it that our electrical processing center...our brain...can actually not just send some electrical signal but actually cause that pain sensation that can be excruciating? Exactly *what* is making that pain?

Think about it.

We are not simply receiving some sort of weak electrical impulse that causes us to notice some hum sound or sensation. No. This pain thing can cause us to writhe around on the ground like a snake...scream...maybe get the hives...maybe pass out.

It's pretty odd if you think about it.

I know. I know. I can hear you already: "What's so odd about it Iamme? It sounds lame." LOL .Ya.

Okay...we know that information sent from the brain somehow gets our muscles to contract, which allow us movement of our muscles which attached to our bones, allow us to move.

But what is there different about the injury impulses that cause us not to just *notice* something, but to actually feel the feeling of the complete force, or cut, or whatever injury was inflicted upon us, in the horrible manner we feel it?

It's easy to simply say that there is this sensitivity. Right now, I took my fingernail and scraped it across the backside of my other hand. I felt *something*. But not real pain. But if I went and say severed the nerve that I just scraped, with a knife? Wow. Extreme pain. Why? If an electrical wire on a telephone pole gets severed, I doubt that the transformer from which it came, starts screaming in pain.

Here's something else that's not exactly what I'm talking about, but still interesting: Our brain tells us what spot we are touching on or skin. We do not feel the senstion in our head. We feel the sensation at the site we just touched. That means that our brain has every spot on and in our body wired in the brain to tell us the exact spot of origin so that it can make us 'sense' that that is the spot we are feeling it at, rather than feeling it in our head. Now that that is said, consider what kind of miniaturized network there must be in the brain that can arrange every spot of every micrometer of our body, so that our brain knows to what spot that feeling belongs. The skin surface area of the outside of our bodies (I'm not even talking about feelings *inside* our body) is A HUGE SURFACE AREA. Yet, our relatively little brains are able to process every spot on our body. That's quite remarkeable.

For the fun of it, move your finger quickly around your hand and up and down your arm. Your brain processes this to let you know 'instantly' where the source of your rub is coming from. Quite amazing.
 
You've actually raised some really important questions. People in the pain research field struggle with these questions all the time.

The first step for you would be to do some reading. Google "Ronald Melzack" and "Gate control theory" and "pain neuromatrix"

The pain in the sprain is mainly in the brain
 
Iamme,
Pain is normally caused by tissue damage to the free nerve endings that causes the release of a neurotransmitter called substance P. But other stimuli can fool the system, like an electrical shock.
But it could be that you're just a whiney little girly-boy.
Why don't you take it like a woman? Ever think about what they go through? Giving birth? Like defecating something the size of a cantaloupe or a watermellon.
Luckily, endophine is an antagonist for substance P and our brains release it when needed. Otherwise, the prolonged birthing process in humans (beacuse of our big heads. Think what ET's mom looked like) would have lead to our extiction.
 
Jeff Corey said:
Iamme,
Pain is normally caused by tissue damage to the free nerve endings that causes the release of a neurotransmitter called substance P. But other stimuli can fool the system, like an electrical shock.
But it could be that you're just a whiney little girly-boy.


I *am* just a whiney girly-boy. Unlike that conservative stud I know on some other board.

Originally posted by Jeff Corey
Why don't you take it like a woman? Ever think about what they go through? Giving birth? Like defecating something the size of a cantaloupe or a watermellon.
Luckily, endophine is an antagonist for substance P and our brains release it when needed. Otherwise, the prolonged birthing process in humans (beacuse of our big heads. Think what ET's mom looked like) would have lead to our extiction.

You mean they would have died from pain? I thought our only hope was that we simply pass out if the pain is overbearing.

________________________________________________

And, Happy Mother's day to your wife, eh?:th:
 
TruthSeeker said:
Jeff, the idea of a specific relationship between injury and pain is no longer widely held. ]

I don't think I implied that. But crush any of your afferent nerves, Mr. Substance P will likely be secreted and Mr. Bill will go, "OOh NOO! Not Sluggo".
 
Jeff Corey said:
I don't think I implied that. But crush any of your afferent nerves, Mr. Substance P will likely be secreted and Mr. Bill will go, "OOh NOO! Not Sluggo".

Absolutely!

Sorry if I misunderstood you. :)
 
Iamme said:
I thought our only hope was that we simply pass out if the pain is overbearing.
That would make it too easy for the predators.
"Look, Spot-big piece of meat is available for lunch.'


________________________________________________

And, Happy Mother's day to your wife, eh?:th:
 
Jeff Corey said:
Giving birth? Like defecating something the size of a cantaloupe or a watermellon.

Yeah, but then they complain about it for several decades.
 
if any woman ever brings up the "it feels like stretching your upper lip over your head" line, i'm going to chop off her hands and ask, politely, if perhaps that isn't a closer analog.
 
TruthSeeker said:
The pain in the sprain is mainly in the brain
Thanks, I'll be sure to tell my right ankle that when it's insisting that it can't walk down the stairs. (Fell off my bike last week!)

Rolfe.
 
Rolfe said:
Thanks, I'll be sure to tell my right ankle that when it's insisting that it can't walk down the stairs. (Fell off my bike last week!)

Rolfe.

Oh! I'm sorry to hear that. I wish you and your brain and your ankle a speedy recovery.

(I could mention how if you were to suddenly lose your leg today, there is a good chance the phantom you would experience would include pain similar to the pain from falling off your bike, but I won't :) )
 
TruthSeeker said:
(I could mention how if you were to suddenly lose your leg today, there is a good chance the phantom you would experience would include pain similar to the pain from falling off your bike, but I won't :) )
I'm grateful for your kindness in not mentioning that! :D

Rolfe.
 
Rolfe said:
Thanks, I'll be sure to tell my right ankle that when it's insisting that it can't walk down the stairs. (Fell off my bike last week!)

Rolfe.

Thought you were going to take up knitting....?
 
Jeff Corey said:
Why don't you take it like a woman? Ever think about what they go through? Giving birth? Like defecating something the size of a cantaloupe or a watermellon.

Thank you for that graphic explanation! :)

Isn't there something about humans having no memory of pain? Women seem to have forgotten all about the pain a while after giving birth...
 
CFLarsen said:
Thank you for that graphic explanation! :)

Isn't there something about humans having no memory of pain? Women seem to have forgotten all about the pain a while after giving birth...

I don't have time to find links at this moment but generally memory for pain starts to change at about 1 week. So,i f you were in the middle of a pain episode and I asked you to rate it (0-10), that number will change after you recover. Some of it is memory distortion just like memory for any other event. Some of it is reinterpretation of the experience in light of what came after. So, if that cramping turned out to be a miscarriage it would be remembered differently than if cramp that turned out to be a baby....

As for childbirth...those interested should try to find "The myth of painless childbirth" by Ronald Melzack. A bit dated but a great paper.
 

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