Let's distinguish two things here. First is Delilo's serious point, second is the funny situations that arise in the books.
"White Noise" is not a comedy. It is an examination of postmodern society. Delilo is describing a world where only what is on television, only what's on the media, is real. The protagonist, his wife, his children, his collegues--all of them lack any real core; they get all their knowledge from the media, and their goal in life is to act in ways that look "good" on television.
...
There is (was?) a college offering a B.A. in "Madonna studies", which makes "Elvis studies" look deep.