With regards to the "blown out of their shoes" precept, I think that's pure Hollywood.
Watch the hunting channel sometime. You can see many real life examples of bullet/shotgun impacts on many different sized targets (typically, shotgun on turkey, and rifle on deer, though they have many other hunts as well).
As an example of your .44 magnum, you'll want to watch the muzzle loader hunts of wild boar.
I have shot quite a few deer at a variety of distances, with my .308, and have not witnessed anything like the "blown out of their shoes" effect.
I shoot a high velocity round at large-man sized animals, and only had the bullet pass through my target animal on 2 occasions. On the first occasion, it took the deers innards with it as the whole mass exited its abdomen. And on the second occasion, it took a fist sized chunk of skull/brain with it as it exited the deers head. Invariably, the animal has, at most, flinched when hit and has not been thrown off balance by the bullet impact.
The "knock down" power you talk about pertains more to ability of the target to function after being struck. The internal damage done is a result of the momentum of the bullet being transferred to the target. Rounds that are deemed to have "knock down" power are designed to transmit their energy to body mass by shredding it or mashing it with a shockwave. To shred tissue, the bullet is designed to fragment on impact, breaking up into smaller pieces that get stopped in the tissue. To mash tissue, the bullet is designed to expand in diameter on impact, causing a shockwave that jellifies tissue.
There is much more to ammunition design, ballistics, and gun design than that, but these are a few things applicable to this discussion.