feeling blue? You need some horse tranquilizers!

andyandy

anthropomorphic ape
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http://news.bbc.co.uk/1/hi/health/5253800.stm

An anaesthetic can treat depression within hours, US research suggests.
The study involving 17 patients found ketamine - used as an anaesthetic but also taken as a recreational drug - relieved symptoms of depression.

Most existing treatments for depression take weeks or even months to relieve people's symptoms.

But the team, writing in Archives of General Psychiatry, said ketamine would need to be altered so it lost its existing hallucinatory side-effects.

This is the first report of any medication or other treatment that results in such a pronounced, rapid, prolonged response


Scientists from the National Institute of Mental Health (NIMH) injected 17 patients with either a very low dose of ketamine or a placebo of saline solution.

The participants were all depression sufferers who had tried an average of six treatments that had failed.

The researchers then measured their levels of depression minutes, hours and days after the dose was given.

Lead researcher Dr Carlos Zarate Junior, head of the mood and anxiety disorders programme at NIMH, said: "Within 110 minutes, half of the patients given ketamine showed a 50% decrease in symptoms."

By the end of day one, he added, 71% had responded to the drug. And at this point the team found 29% of these patients were nearly symptom free.

The researchers also discovered one dose lasted for at least a week in more than one-third of the participants.

so when you see a horse walking around with a long face....you know it's not had its ketamine :D
 
for non-uk residents....http://www.guardian.co.uk/drugs/Story/0,2763,720588,00.html

Only fools and horses take the drug ketamine, if scriptwriters of The Archers are to be believed. Fools such as Jazzer McCreary, a Glaswegian transplanted to Ambridge and found unconscious on the toilet floor of the local pub, The Bull, prompting landlord Sid Perks to declare that the young tearaway had only himself to blame for his subsequent trip to intensive care. Like many a Radio 4 listener, no doubt, Sid can't understand why anybody would deliberately ingest a horse anaesthetic. Ketamine - also known as "Special K" - is, after all, a drug that vets use specifically to avoid kicks.
If you thought that Special K was just a breakfast cereal, then you are not alone. Ketamine was a relatively low-profile drug until its outing on Britain's longest-running soap opera. Supplying it to others is illegal under the Medicines Act. Possession, on the other hand, is not an offence because, unlike the better known ecstasy, ketamine is not yet classified under the Misuse of Drugs Act. Its misuse, however, is not confined to country boys. Frequenters of dance clubs, squat parties and rock festivals have been aware of it since the early 90s.

"A colleague of mine saw it in tablet form, cut with other substances, at last year's Reading festival," says Dr Simon Underhill, senior anaesthetist at Wrexham Maeler hospital. "He found people zonked out, in a very strange state."

But when they came round, would they suffer from permanent short-term memory loss, like Jazzer?

"Ketamine wouldn't do that on its own because it maintains heart and blood levels," says Underhill, one of several experts consulted over the Archers storyline. "My advice was that he should inhale vomit while under its effects. That could give him severe pneumonia which, in turn, would reduce oxygen levels and impair the nervous system."

This is not an unlikely scenario. Regular users quickly build tolerance and the more ketamine taken, the higher the chance of passing into a lengthy coma. "Some people do become dependent on ketamine in a way that resembles cocaine dependence, with craving," says Underhill. "However, there is no withdrawal syndrome if the drug is stopped."

With higher doses (200mg or more), unconsciousness may be preceded by numbness of the limbs, strange muscle movements and nausea. And the dangers are exacerbated if it is used at the same time as depressants, such as alcohol, barbiturates, heroin or tranquillisers.
 
It's not a vet anaesthetic - it has a long history of use in human medicine. It is extremely useful, particularly in 2 situations - one where the surgeon needs to administer the anaesthetic as well as doing the operation (say a single handed doc doing rural emergency work) because once given it needs little monitoring. It is useful in trauma because unlike other anesthetics it has no myocardial depressant effect and maintains blood pressure and perfusion - useful if someone is already shocked because of blood loss. We also used to use it with kids because it was quite easy and gentle to administer.
One prob was the propensity for recipients to have vivid hallucinations on wakening, particularly if roused suddenly. We would give the patients a big sticker on their foreheads saying - "Ketamine - do not disturb!" so that they would be allowed to wake slowly and naturally.
 
We would give the patients a big sticker on their foreheads saying "Ketamine - do not disturb!" so that they would be allowed to wake slowly and naturally.
you could make a fortune selling those stickers at the local "head" shop...
 
My son was given ketamine twice while having knee aspirations. I don't think he had hallucinations, but he was only 20 and 22 months old when they were done.
 
The vet is coming later, perhaps to put one of my dogs to sleep. Maybe I'll get some ketamine while he's at it.
 
It's not a vet anaesthetic - it has a long history of use in human medicine.

it's not just a vet anaesthetic....

just out of interest, how much leeway is there for docs to prescribe drugs such as ketamine for treatment in areas in which it hasn't been officially licensed?

In the UK i think NICE sorts all drug licensing out - but what about existing drugs? say follow up studies showed that ketamine did seem to offer a way of treating depression - and that i as a doc thought a patient was a suicide risk, could i prescribe it before it had formally been approved in this new area?
Or would i be slung out on my many lettered ass?
 
It's not a vet anaesthetic - it has a long history of use in human medicine. It is extremely useful, particularly in 2 situations - one where the surgeon needs to administer the anaesthetic as well as doing the operation (say a single handed doc doing rural emergency work) because once given it needs little monitoring. It is useful in trauma because unlike other anesthetics it has no myocardial depressant effect and maintains blood pressure and perfusion - useful if someone is already shocked because of blood loss. We also used to use it with kids because it was quite easy and gentle to administer.
One prob was the propensity for recipients to have vivid hallucinations on wakening, particularly if roused suddenly. We would give the patients a big sticker on their foreheads saying - "Ketamine - do not disturb!" so that they would be allowed to wake slowly and naturally.
It is a terrible human anesthetic, there are several reports of longlasting nightmares.

If you give benzodiazepines before giving Ketamine, this complication is reduced, but not eliminated. But then, you need a nurse anesthetist or anesthesiologist to monitor the patient.

A chairman of a respected American Residency program informed his residents that Ketamine was "instant madness" after he had experimented with it (many years ago, I suspect nobody now would even admit to this "experiment").

Don't forget the close cousin PCP, a true vet anesthetic and well known to induce bad trips in the drug culture.
 
In her true crime book "A Rage To Kill and Other Cases," Ann Rull told the story of Marcia Moore, a woo writer who took a lot of ketamine, trying to become psychic or enlightened. She died one night, and the body was not discovered for some time. Maybe she froze to death in a drug-induced haze, or maybe she was murdered.
 
Why does it work?

My ballpark guess would be that it speeds up the immobilizing effects of depressions, putting it into full blown effect, possibly triggering the body to counter it upon recovery from the medication, lightening the patient's mood.

But that's hardly even an educated guess.
 

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