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Scientists find gene that links migraine with colder climes

Vixen

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Vixen
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If you suffer from migraine, the culprit could be a gene labelled TRPM8


The researchers discovered that a variant of the gene has become increasingly common in people living in higher latitudes over the last 25,000 years.

Scientists had previously identified the variant as being strongly associated with migraines.

They discovered that 88 percent of people with Finnish ancestry carried the variant, compared with only 5 percent of people with Nigerian ancestry.

The genetic variation was, and still is, rare in Africa, but is now common outside of the continent.
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The researchers:

Felix Key of the Max Planck Institute based in Germany, examined TRPM8, a gene that codes for the only known receptor that enables a person to detect and respond to cool and cold temperatures.
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http://www.dailymail.co.uk/sciencet...tic-mutation-cold-predisposing-headaches.html

This is interesting as I know so many people who claim never to have had a headache in their life, when I had assumed everybody has them now and then.
 
and class, what does the cold sensation do? Probably effects the circulation- to the brain?
 
Mine are usually caused by heat or glare, or I wake up with it.

As for genetics my mother never had a headache in her life, nor my sibling.
 
Vixen said:
As for genetics my mother never had a headache in her life, nor my sibling.
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Aw, you should have told the Max Planck Institute, the Migraine Research Foundation, and the world's medical community about your mother and sibling. Think of all the millions they could have saved in unnecessary research, if they'd known genetic causes have already been completely ruled out. :mad:
 
Darat said:
This article seems to be talking about migraines not headaches?
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I just checked my 23&me raw data. About 70 gene SNPs listed fir TRPM8. Add in the monoamonoxidase enzyme, and that is a LOT of data to sift through.

But yeah, migraines run in the family. Siblings, nieces and nephews... And mine were never painful, no headache involved. But the visual aura, numbness of one side of face and an arm. Goes away if I can fall asleep, but leaves me with a hangover.
 
Myriad said:
Aw, you should have told the Max Planck Institute, the Migraine Research Foundation, and the world's medical community about your mother and sibling. Think of all the millions they could have saved in unnecessary research, if they'd known genetic causes have already been completely ruled out. :mad:
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Did Vixen seem to argue that the science was wrong?!
 
casebro said:
I just checked my 23&me raw data. About 70 gene SNPs listed fir TRPM8. Add in the monoamonoxidase enzyme, and that is a LOT of data to sift through.

But yeah, migraines run in the family. Siblings, nieces and nephews... And mine were never painful, no headache involved. But the visual aura, numbness of one side of face and an arm. Goes away if I can fall asleep, but leaves me with a hangover.
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I just ran through my 23+me raw data for TRPM8 and there are apx 65 markers for this on my SNP's.

My migraines usually begin with an aura - bright colours, wavy lines, black specks - and often, a sudden disappearance of one of my visual fields (usually the right side), the whole side of a newspaper being read, vanishes! feelings of nausea, heat, followed by a terrible headache.

My doctor gave me some uptake inhibitor tablets (sumatriptan) and some other, anti-nausea pill, which you put under your lip for it to dissolve. The former successfully immediately aborts the migraine, the other makes you feel weird (I heard that they had to take it off being an over the counter drug, as druggies were buying them to get drug highs, someone else told me it was an anti-psychotic).

Unfortunately the effect of sumatriptan was to make me feel as though the whole of one side is paralysed. So unpleasant, I prefer to just suffer the migraine, with the help of Aspirin.

Nobody else in my family I know of has it. Although it's possible they just haven't mentioned it.
 
What I was referring to is that my sisters & I all had ancestral DNA analyses done last year. I turned out to have 11% Finnish/Saami heritage, whereas my sisters have 3% and zero respectively. So it would make a certain amount of sense that I'm more likely to have that gene variant. I am the only migraneur of the three of us. I'm also the most Neanderthal of the three of us *grin*
 
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