The motivation report can only favour the defence, as it can provide grounds for appeal. For those who believe Sollecito and Knox are subject to a miscarriage of justice, that they have been wrongfully convicted is the essence of a miscarriage of justice. If conviction is confirmed by the ISC it will remain wrong. This is not a unique feature of Italian justice. In the UK it is recognised that despite undertaking all appeals wrongful convictions still occur and there is an 'extrajudicial' process to review cases.
I think the devil will be in the detail, and until a good translation is available we can just speculate. In addition I certainly do not know what the Italian legal system permits.
So just to speculate. The motivation of theft leaves room for appeal for all three. If there is no sexual motive then the charge should be simple homicide. For Guede this would be sixteen years reduced by the fast track appeal, such that he should now be released.
The use of Guede as witness against Knox when the statement was obtained from a police interview and not a witness statement in court and contradicted the Skype conversation where he said Knox was not present would seem grounds for appeal. The defence should have had a chance to cross examine a witness against their client. Since the witness said both Knox was present and absent there would need to be some grounds to justify which choice was made.
The statement that there was a planned meeting by Guede, Sollecito and Knox might be grounds for appeal, as there is no evidence for this. Alternatively as for the knife transport argument, this may be allowable under the Italian system as being a logical prequel to the evidence presented. Having established that Sollecito, Guede and Knox jointly committed a murder it is only logical to conclude that they must have arranged to meet. Just as having concluded that MK was murdered with the knife from Sollecito's flat there was a need for a logical prequel to explain the presence of the knife. The telephone records should establish that Guede did not contact (or vice versa) either Sollecito or Knox by telephone, letter would seem unlikely, especially as up until very shortly before both Knox and Sollecito expected to be elsewhere. Email is excluded as this would have been recorded. Popovic called on Sollecito about 20.20, so if Guede called round (even though he did not know Sollecito) to arrange a meeting it would need to be after that. If only the CCTV records had been preserved! So somehow we have an hour gap in which between Popovic leaving and Naruto playing Guede has to arrange a meet. Then Sollecito and Knox have to appear in the baseball court, without Guede who has already gone round to the flat, since he has to be present when Knox gets in to be confronted by MK over the missing money. Sollecito or Knox had to have brought over the knife. The telephones have to be played with and dumped. It is really very tight to fit in the argument, and allow it to escalate to murder during the duration of Guede's defaecation especially as he was not constipated.