Studying the pharmacological profile of drugs does little to understand their subjective effects.
However, experiencing all the subjective effects, and then noting that these subjective effects are the result of a molecule which enters the brain, diffuses into synapses and binds to neurotransmitter receptors or ion channels thereby interfering with normal synaptic transmission, leads one to the conclusion that altered synaptic transmission alters subjective experience. (Conversely, subjective experience reduces to synaptic activity).
This inescapable conclusion, together with understanding the effects of brain damage and brain stimulation, combine to make a very strong case that all of subjective experience is strictly a manifestation of brain activity.