If I were collecting data as a crowd control consultant and taking what I've seen here as indicative of how to respond to something such as we saw at UC Davis, I'd have to recommend against using the pepper spray. This isn't because it's particular dangerous but because it projects a poor image. It "just looks wrong" rather than being particularly life-threatening.
The second most common recommendation here was to manhandle the individuals (presumably into a police van). This apparently "looks better" although the opportunity for injury to either the officers or the perpetrators probably increases with this option.
Perhaps a better alternative is to erect some kind of fence perimeter around the perpetrators and post guards. Nobody is harmed and it has the added advantage of "looking better". It also separates the perpetrators both from the officers and from passersby or potential reinforcements. Once any of the perpetrators requires food, rest, medical aid, or restroom facilities, the guard in place may allow them to exit and alternately release them or place them under arrest as the law warrants.
See? All fixed!