ElMondoHummus
0.25 short of being half-witted
So they used salt and cyclodextrin, both of which are water soluable? All right. Then clumping would have indeed been something strange and new... had it been replicated. But as skeptigirl points out, the lack of such confirmation is pretty damn telling.
Now, I'll note that the various forms of cyclodextrin (it's not a single molecule; rather, it's a class of cyclic oligosaccharides i.e. rings of sugar) have both a hydrophilic exterior (thus giving it water solubility) and a less hydrophilic interior which can house hydrophobic compounds. So if aggregation did occur in an experiment using cyclodextrin, I'd immediately want to know if there was a contaminant present that could have been picked up by those sugar rings (or present with them from the beginning) which could have led to such aggregation. Until that's ruled out via replication of the experiment with known pure water and known uncontaminated cyclodextrin, I'm not ready to accept the conclusions of the original experiement as demonstrating clumping of otherwise soluble molecules. The result has to be replicated, and other possibilities - such as a hydrophobic molecule encircled by the cyclodextrin - must be eliminated before such a thesis carries any weight.
Now, I'll note that the various forms of cyclodextrin (it's not a single molecule; rather, it's a class of cyclic oligosaccharides i.e. rings of sugar) have both a hydrophilic exterior (thus giving it water solubility) and a less hydrophilic interior which can house hydrophobic compounds. So if aggregation did occur in an experiment using cyclodextrin, I'd immediately want to know if there was a contaminant present that could have been picked up by those sugar rings (or present with them from the beginning) which could have led to such aggregation. Until that's ruled out via replication of the experiment with known pure water and known uncontaminated cyclodextrin, I'm not ready to accept the conclusions of the original experiement as demonstrating clumping of otherwise soluble molecules. The result has to be replicated, and other possibilities - such as a hydrophobic molecule encircled by the cyclodextrin - must be eliminated before such a thesis carries any weight.