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Cont: The One Covid-19 Science and Medicine Thread Part 5

2024-25 COVID vaccine 80% effective against death, CDC estimates (CIDRAP, Feb 4, 2026)
The 2024-25 COVID-19 vaccine was an estimated 40% effective against hospital admission and 79% effective against invasive mechanical ventilation (IMV) or death, with similar efficacy against the KP.3.1.1 and XEC variants, although with considerable uncertainty, researchers from the US Centers for Disease Control and Prevention (CDC) reported yesterday in JAMA Network Open.
 
I for one, would be happier if more health professionals, and patients, wore masks all the time in clinical settings.

People catching covid while attending medical services for some other reason, is very much a thing.

:(
 
MedPage Today reported, "Official U.S. counts of COVID-19 deaths likely missed over 150,000 unrecognized mortalities during the pandemic's first 2 years, a machine learning model study suggested...Study limitations include the assumption that the machine learning model's training data set of inpatient deaths assigned to COVID-19 was correct." I don't have any opinion on the correctness of this study.
 

Study Points to Massive Undercount of Early COVID Deaths in the U.S.​

— Official count may have missed more than 150,000 coronavirus-related fatalities​

The actual number of US deaths caused by severe acute respiratory syndrome coronavirus 2 infection has been investigated and debated since the start of the COVID-19 pandemic. Here, we use machine learning trained on US death certificates from March 2020 to December 2021 to predict 155,536 (95% uncertainty interval: 150,062 to 161,112) unrecognized COVID-19 deaths. This indicates that 19% more COVID-19 deaths occurred in the US than officially reported. Predicted unrecognized COVID-19 deaths occurred disproportionately among decedents with less than a high school education; decedents identified as Hispanic, American Indian, Alaska Native, Asian, and/or Black; counties with lower household incomes and worse preexisting health; and counties in the South. These findings suggest that the US death investigation system undercounted COVID-19 deaths unevenly, hiding the true extent of inequities.
I see Chris also posted this first.
 
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MedPage Today reported, "Official U.S. counts of COVID-19 deaths likely missed over 150,000 unrecognized mortalities during the pandemic's first 2 years, a machine learning model study suggested...Study limitations include the assumption that the machine learning model's training data set of inpatient deaths assigned to COVID-19 was correct." I don't have any opinion on the correctness of this study.
Yeah, this undercount is an issue. What's worse is that it hasn't been getting any better from 2023 onward.

Here's a paper discussing the impact of C19 for the next decade:

A PNAS paper on excess deaths. Based on current CDC data it's optimistic.

Perhaps the CDC's C19 and excess mortality page is the most disturbing:

Check the tables and then go down to Figure 1 which shows death rates from 2015. One can clearly see the effect of C19 waves from 2020 to the fir 3 months of 2022. After that they are blended in with flu and other winter seasonal increases in mortality. HOWEVER, look at the yearly excess deaths during the months after that. Pretty consistent excess death rates of just under 10% and they don't have much peaking during the C19 waves. In the tables, which show annual, monthly or weekly details, C19 deaths are a small percentage of the excess deaths and less than 10% of the excess in the last 12 months.
 
💉 💉 💉:
COVID vaccines not tied to risk of sudden death, study shows (CIDRAP, Mar 23, 2026)
Data show that young, healthy people have no additional risk of sudden death if they are vaccinated against COVID-19, contrary to myths that continue to circulate widely on social media.
In fact, healthy adolescents and young adults vaccinated against COVID-19 were 43% less likely to experience sudden death than non-vaccinated people, according to a Canadian case-control study published last week in PLOS Medicine.

Long COVID:
Up to 60% of health care workers may have long COVID 4 years after infection (CIDRAP, Mar 20, 2026)
Four years after infection with the wild-type SARS-CoV-2 strain, up to 60% of health care workers (HCWs) in Switzerland still reported at least one COVID-19 symptom, although the number of participants dwindled over time, Swiss researchers write in Infection.
From 2022 to 2024, the team tracked 24 COVID-19 symptoms among 456 HCWs who self-reported infection with the original SARS-CoV-2 strain and 571 uninfected controls at 14 centers. Participants completed an online survey at baseline and every six months and underwent serologic testing to identify any asymptomatic infections. The median participant age was 44 years, and 80.6% were women.

About RFK Jr.'s Advisory Committee on Immunization Practices (ACIP) and its false claims:
CIDRAP Op-Ed: The report that proves the point—ACIP, COVID vaccines, and predetermined conclusions (CIDRAP, Mar 19, 2026)
 
Long COVID:

You are using the identical tactics as RFK.

RFK uses incorrect, biased or outright fabricated "evidence", and you link to a study on long covid that is badly constructed, unscientific and doesn't even support your idiotic claim.

From YOUR link:

From 2022 to 2024, the team tracked 24 COVID-19 symptoms among 456 HCWs who self-reported infection with the original SARS-CoV-2 strain and 571 uninfected controls at 14 centers.

571 uninfected health workers? I call utter BS on that. I doubt there are 571 health workers on the planet who haven't had covid at least once. Serological testing for asymptomatic infection was carried out, but it doesn't appear that people were tested for past infection, with the 571 being self-reportedly free of previous infection. Given the high chance of asypmtomatic infections, that number is fantasy.

A total of 72.0% of participants lacked complete data or were lost to follow-up during the study.


Reaching conclusions based on a measly 28% of the original group? That ain't science, it's it barely qualifies as guesswork. Spock would be disgusted.

And the final nail in the coffin:

At the final follow-up, only 18 of the remaining 70 participants remained, with 14 (78%) indicating ongoing subjective long COVID. Scores on the Post-COVID Functional Status scale showed slight impairment in most participants, but moderate to severe limitations often lingered.

"Subjective". Even with only those kidding themselves they're sick, the numbers are negligible.

You do science no favours by passing off studies like that as scientific, relevant, or useful in any form. The very best way to not counter misinformation is to post equally-stupid misinformation.

Good work!
 
Quite a good study looking in detail at the spread of respiratory viruses in families with children, from 2020 to 2022; the study reports on SARS CoV 2 infection / covid.
1) Adults were more infectious than children. If the primary case in a family was an adult then there were more secondary cases than if the primary case were a child (this is the opposite of what is seen with flu).
2) Vaccination didn't affect infectiousness. A vaccinated primary case spread the infection to the same extent as an unvaccinated primary case.
3) Unvaccinated people had a higher risk of being infected by a family member than unvaccinated.

SARS-CoV-2 seroprevalence and seroconversion in Finnish households with school-aged children between June 2020 and April 2022.​

Jaakko Ahti, Helena Ollila, Laura Toivonen, Krista Salo-Tuominen, Lauri Ivaska, Ilkka Julkunen, Ville Peltola
Infectious Diseases 2026 March 29
CONCLUSION: In this study, adults spread SARS-CoV-2 in households more efficiently than children. While the index case vaccination status showed no difference, unvaccinated household members were more prone to SARS-CoV-2 infection than vaccinated individuals.
Key points
A cohort of households with children was prospectively studied for SARS-CoV-2 transmission through repeated PCR, and serology was obtained 5 weeks post-infection.
Adults transmitted the virus more effectively than children, and unvaccinated participants were more susceptible than vaccinated participants.
 
A The-Atheist fantasy:
You are using the identical tactics as RFK.
RFK uses incorrect, biased or outright fabricated "evidence", and you link to a study on long covid that is badly constructed, unscientific and doesn't even support your idiotic claim.
From YOUR link:
From 2022 to 2024, the team tracked 24 COVID-19 symptoms among 456 HCWs who self-reported infection with the original SARS-CoV-2 strain and 571 uninfected controls at 14 centers.
571 uninfected health workers? I call utter BS on that. I doubt there are 571 health workers on the planet who haven't had covid at least once. Serological testing for asymptomatic infection was carried out, but it doesn't appear that people were tested for past infection, with the 571 being self-reportedly free of previous infection. Given the high chance of asypmtomatic infections, that number is fantasy.
A total of 72.0% of participants lacked complete data or were lost to follow-up during the study.
Reaching conclusions based on a measly 28% of the original group? That ain't science, it's it barely qualifies as guesswork. Spock would be disgusted. And the final nail in the coffin:
At the final follow-up, only 18 of the remaining 70 participants remained, with 14 (78%) indicating ongoing subjective long COVID. Scores on the Post-COVID Functional Status scale showed slight impairment in most participants, but moderate to severe limitations often lingered.
"Subjective". Even with only those kidding themselves they're sick, the numbers are negligible.
You do science no favours by passing off studies like that as scientific, relevant, or useful in any form. The very best way to not counter misinformation is to post equally-stupid misinformation.
Good work!
No, I'm obviously not "using the identical tactics as RFK." The Atheist is!
Unlike RFK Jr., I link to a study that isn't badly constructed, unscientific or doesn't support my claim. It would be interesting to hear what exactly my alleged claim is supposed to be since I made no claims, which makes the claim that I did make a claim perfectly idiotic and entirely made up. However, this is the kind of argumentation that we have come to expect from The Atheist.
As for MY link: Yes, unlike The Atheist, I usually include not only links but also quotations from those links, which is what I did in this case, too!
And unlike The Atheist, I don't rely on calling "utter BS" on things that I "doubt." Nor do I make up predictions base on what I would like to be true but with no documentation or facts to back them up.
The Atheist's argumentative tactics in this case is to sow doubt about a study while pretending that the study makes claims that aren't warranted.
He does so by pretending that I "do science no favours by passing off studies like that as scientific, relevant, or useful in any form."
However, the study doesn't make any claims that are misinformation. In order to show this were the case, The Atheist would have to show it to be the case, i.e. that the study were misinformation, but he doesn't. Instead, he does the exact opposite: He quotes sentences from the article that show awareness of the limitations of that study, i.e.
"From 2022 to 2024, the team tracked 24 COVID-19 symptoms among 456 HCWs who self-reported infection with the original SARS-CoV-2 strain and 571 uninfected controls at 14 centers."
(...)
A total of 72.0% of participants lacked complete data or were lost to follow-up during the study.
(...)
"At the final follow-up, only 18 of the remaining 70 participants remained, with 14 (78%) indicating ongoing subjective long COVID. Scores on the Post-COVID Functional Status scale showed slight impairment in most participants, but moderate to severe limitations often lingered." And he adds: ""Subjective". Even with only those kidding themselves they're sick, the numbers are negligible."

The Atheist's trick is to pretend that an article that actually points out the limitations of the study it presents can be used as a gotcha exactly because it presents those limitations. In this respect, the article is very open and honest, something that The Atheist has never been when he presents his fever fantasies about the pandemic or, in this case, about claims that neither the article, the study it's based on nor I, when I linked to the article, ever made.

If the article and the study had left out the limitations and pretended that it was rock-hard evidence of something, it could have been blamed for being "equally-stupid misinformation." As it is, The Atheist is the one who continues to use "the identical tactics as RFK."
 
Jay Bhattacharya delays publication of study about the efficacy of COVID-19 vaccinations in the fall of 2025:
CDC delays report on COVID vaccines (CIDRAP, April 9, 2026)
According to the unpublished report, which was shared with the Post, from September to December last year, people who had received an updated seasonal COVID vaccine reduced their likelihood of ED and urgent care visits by 50% and the likelihood of COVID-associated hospitalizations by 55%.

WaPo bombshell: RFK's CDC burying report on Covid vaccine success (MS NOW on YouTube, April 10, 2026 - 9:29 min.)
The Washington Post reports the CDC is sitting on a public health report that was supposed to have been published two weeks ago—a report that showed the ongoing success of the Covid vaccine. Michigan Senate candidate and epidemiologist Abdul El-Sayed joins to discuss.
 
Robin Broshi on bsky, April 10, 2026
Everyone who said we should listen to the doctors who supported dropping Covid mitigations is responsible for this ◊◊◊◊◊◊◊ mess

Jonathan Howard on bsky, April 10, 2026
As our Mad King spirals further, MAHA doctors are there to support him with declarations of love.
My thoughts on what this means for them and their sycophants.
sciencebasedmedicine.org/maha-doctors...
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As our Mad King threatens to wipe out whole civilizations with MAHA doctors at his back, I’d like to reiterate two points I’ve made previously.
First, this explains why it was both dangerous for “respectable” doctors to falsely portray MAHA doctors as “apolitical”, good faith actors and reprehensible for them to mock those who warned of their obvious danger. These sycophants did far more than disregard the COVID disinformation of MAHA doctors, though that is shameful enough, they also legitimized their political endorsements. When MAGA 2.0 and MAHA were on the rise, many of us stuck out our necks to sound the alarm bell. In contrast, the enablers rolled out the red carpet, even if they are now oh-so horrified by what they helped unleash on us all.
 
🫀🫀🫀
Long COVID tied to higher risk of heart disease, even after mild infection (CIDRAP, April 10, 2026)
A diagnosis of long COVID is associated with an increased risk of cardiovascular disease, particularly cardiac arrhythmias, heart failure, and coronary artery disease, even among patients who were not hospitalized for COVID-19, according to a new prospective cohort study published in eClinicalMedicine.
(...)
Long COVID is increasingly recognized as a significant public health concern, affecting an estimated 10% to 30% of people. Initially, researchers and clinicians focused on fatigue and respiratory and autonomic nervous system issues as the main symptoms of long COVID, but growing evidence suggests that infection may have lasting effects on the cardiovascular system, likely driven by endothelial dysfunction, chronic inflammation, and myocardial injury.
 
A diagnosis of long COVID is associated with an increased risk of cardiovascular disease, particularly cardiac arrhythmias, heart failure, and coronary artery disease, even among patients who were not hospitalized for COVID-19, according to a new prospective cohort study published in eClinicalMedicine.
This is consistent with the excess death CDC data:

See
Table 1. Provisional death counts by time period and jurisdiction, United States.

Since the end of Dec., there is a consistent excess death rate of around 5% while less than 1% of these deaths are flagged on death certs. as Covid. This is the long term effect of 6 years of Covid infections on general mortality.
 
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About two years ago Paul Offit had a long retrospective discussion with Doctor Mike. Speaking about the development of the mRNA vaccines against Covid-19 (the period from about January 2020 to July 2021, Paul Offit said, “I think that that year and a half was the greatest medical or scientific achievement of my lifetime.” This is similar to what Eric Topol said.
 
This is the long term effect of 6 years of Covid infections on general mortality.

Given that we know the vaccines work and protect from severe illness it's a shame the chief medical voice in USA is a lying antivax scumbag, or more people would get the vaccine.

I'm constantly amazed that people I know over 60 don't get vaccinated, but they don't care. People prefer YouTube to medical science. The reach of Kennedy, Trump* et al extends a long way.

Ho hum.

*I bet he quietly gets the vaccine, because he thought he was a dead man walking when he got in the chopper.
 

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