The ECHR requires claimants to exhaust all internal avenues of complaint first (except for Article 3: torture). Amanda falls at the first hurdle. She didn't complain to the Police Complaints Commission in Italy, she didn't complain to the US amabassador who visited her in jail regularly, her brief, Ghirgha, denied there had been any ill-treatment and Amanda herself testified her treatment was fine. In her Prison Diary she bragged of how excellent the prison conditions were, and settled in very well (as psychopaths are known to do).
Bruno-Marasca did not throw her a crumb of comfort (their verdict was geared towards their Raff paymasters) and scathingly described her calumny as being a cover up for Rudy, co-murderer.
Epic fail.
The above post misrepresents ECHR case-law.
1. It is true that the Convention requires that domestic remedies be exhausted before a case is brought before the ECHR. However, ECHR case-law is quite clear: the domestic remedies needed to be tried are only those that are available and likely to succeed. In practice, this means that the applicant to the ECHR must have had a final decision from the highest available domestic court (or similar authority). This is exactly the situation in the case of Amanda Knox having been finally convicted of calunnia against Lumumba; this final conviction was from the CSC, and no further appeal was possible. ECHR case-law specifically states that extraordinary remedies, such as pardons from the government, are not required and are not at all considered available and practical remedies.
2. In fact, the ECHR requires exhaustion of domestic remedies even for alleged violations of Convention Article 3, with the exception only of those cases where there is an imminent potential threat of torture or to life - for example, in cases where an applicant may be extradited to a country outside the Council of Europe States where there is reputed to be essentially no protection of human rights. Such cases are addressed through interim measures, which freeze the action of the CoE State until the ECHR can examine the case and make a ruling.
In most cases involving allegations of torture in CoE States, the victim only has the opportunity to fax or write to the ECHR after commission of the torture. Thus, the alleged victim has the opportunity to work through the domestic authorities, including the courts, to seek redress, before applying to the ECHR.
3. Specifically in terms of Amanda Knox's case, she notified the Italian authorities of her mistreatment in her Memoriale 1 written and delivered to police on 6 November 2007. The obligation of the police and prosecutor at that time, upon receipt of that note, according to ECHR case-law, was to launch an independent and effective investigation of her complaint, which may have included seeking to have her fill out any official complaint form required under Italian practice or law. The Italian authorities did not fulfill those responsibilities.
Similarly, after Knox announced in court in 2009 that she had suffered mistreatment during the November 5/6 interrogation, the authorities did not conduct an effective and independent investigation of her allegations. Under ECHR case-law, that was there obligation. Instead, the authorities charged her with calunnia against the police, an obvious effort of intimidation.
Knox and her lawyers cited the mistreatment during the interrogation in each of her appeals against the calunnia against Lumumba charge, including the appeal to the Chieffi CSC panel which delivered her final conviction on that charge.
Thus, she fully exercised the exhaustion of domestic remedies according to ECHR case-law.
The other alleged remedies you write about, such as complaining to the US ambassador, are irrelevant under ECHR case-law.