The existence of preserved soft tissue remains and DNA of woolly mammoths has led to the idea that the species could be recreated by scientific means. Two methods have been proposed to achieve this. The first is cloning, which would involve removal of the DNA-containing nucleus of the egg cell of a female elephant, and replacement with a nucleus from woolly mammoth tissue. The cell would then be stimulated into dividing, and inserted back into a female elephant. The resulting calf would have the genes of the woolly mammoth, although its fetal environment would be different. To date, even the most intact mammoths have had little usable DNA because of their conditions of preservation. There is not enough to guide the production of an embryo.
The second method involves artificially inseminating an elephant egg cell with sperm cells from a frozen woolly mammoth carcass. The resulting offspring would be an elephant–mammoth hybrid, and the process would have to be repeated so more hybrids could be used in breeding. After several generations of cross-breeding these hybrids, an almost pure woolly mammoth would be produced. The fact that sperm cells of modern mammals are potent for 15 years at most after deep-freezing is a hindrance to this method. In one case, an Asian elephant and an African elephant produced a live calf named Motty, but it died of defects at less than two weeks old.
In 2008, a Japanese team found usable DNA in the brains of mice that had been frozen for 16 years. They hope to use similar methods to find usable mammoth DNA. In 2009, the Pyrenean Ibex (a subspecies of the Spanish ibex) was the first extinct animal to be cloned back to life; the clone lived for only seven minutes before dying of lung defects. As the woolly mammoth genome has been mapped, it may be possible to recreate a complete set of woolly mammoth chromosomes in the future by adding mammoth-only sequences to elephant chromosomes. If the process is ever successful, there are plans to introduce cloned woolly mammoths to Pleistocene Park, a wildlife reserve in Siberia.
Mammoth expert Adrian Lister questions the ethics of such recreation attempts. In addition to the technical problems, he notes that there is not much habitat left that would be suitable for woolly mammoths. Because the species was social and gregarious, creating a few specimens would not be ideal. He also notes that the time and resources required would be enormous, and that the scientific benefits would be unclear; he suggests these resources should instead be used to preserve extant elephant species which are endangered. A 2014 article about potential cloning also questioned the ethics of using elephants as surrogate mothers, as most embryos would not survive, and noted that it would be impossible to know the exact needs of a resurrected calf.