"I have to ask straight up, what is so special about Meredith that she needed to be assassinated?"
That is a question that we need to find an answer to.
I read about how she was killed by Rudy because he was in the house to commit a burglary and when Meridith came home he killed her so that she would not be a witness to his crime.
I just can't believe someone would kill Meredith for that reason.
Maybe that is because I am a Christian so I believe human life is sacred, but we also must consider that Rudy has committed other burglaries and was not punished, I don't think he would commit a murder to avoid being caught for burglary.
What he could have done is used toilet paper to wrap up his head like he was a mummy and ran while holding his knife and Meridith would have just let him pass, and then he could have run away and Meridith would not see his face.
According to the autopsy it appears he did something like what the marines call a "sentry removal". To kill a sentry without making any noise that would alert the guys he was guarding, you make a sneak attack and slash the sentry's throat. If done right the victim is disabled as soon as he knows he is attacked, and cannot scream.
Rudy had those computers so he could have googled murder and learned about this technique. He was not able to practice it so he did a sloppy job and a bone got in the way of his knife and he had to make 3 cuts. Therefore he had already decided he was gonna kill Meridith, and that is why he was there.